SynthesisPloS one2019
HR-pQCT imaging in children, adolescents and young adults: Systematic review and subgroup meta-analysis of normative data.
Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Recent advances in research on the association between paediatric hyperuricaemia and bone health.Frontiers in endocrinology · 2026Pooled it
- Bone microstructural and strength changes over 1 year in children with osteogenesis imperfecta are comparable to age- and sex-matched healthy controls.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Impaired bone health after pediatric acute lymphoblastic leukemia treatment despite normal DXA: insights from high-resolution peripheral quantitative computed tomography.Frontiers in endocrinology · 2026Article
- Article
- Association of daily physical activity and bone microarchitecture in young adults with type 1 diabetes - A pilot exploratory study.Bone reports · 2024Article
- Impaired bone mineral density and microarchitecture in female adolescents with IgE-mediated cow's milk allergy.Archives of osteoporosis · 2024Observational
- Deep Convolutional Neural Networks Provide Motion Grading for High-Resolution Peripheral Quantitative Computed Tomography of the Scaphoid.Diagnostics (Basel, Switzerland) · 2024Article
- The impact of motion induced artifacts in the evaluation of HR-pQCT scans of the scaphoid bone: an assessment of inter- and intraobserver variability and quantitative parameters.Quantitative imaging in medicine and surgery · 2023Article
- Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes.Frontiers in endocrinology · 2023Article
- Identifying Bone Matrix Impairments in a Mouse Model of Neurofibromatosis Type 1 (NF1) by Clinically Translatable Techniques.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Laparoscopic Versus Open Colorectal Surgery in the Emergency Setting: A Systematic Review and Meta-analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2021Article
- Impact of Type 1 Diabetes Mellitus on Skeletal Integrity and Strength in Adolescents as Assessed by HRpQCT.JBMR plus · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aimed to investigate the methodologies on image acquisition of normative data of high-resolution peripheral quantitative computed tomography (HR-pQCT) in children, adolescents and/or young adults (up to 25 years) and to determine their normative data based on available literature. A literature search was conducted in MEDLINE, EMBASE and Web of Science from 1947 to July 2019. Quality of articles was assessed using Standards for Reporting of Diagnostic Accuracy (STARD) scoring system and Modified Newcastle-Ottawa scale (NOS). Articles which fitted the following criteria were combined to meta-analysis: age range (15 to 22.6 years), references at tibia (22.5mm) and/or radius (9.0 to 9.5mm). Eight articles were ultimately included in the systematic review and 4 of them that filled the criteria were summarised in meta-analysis. The results of random effects model of HR-pQCT parameters of the 4 articles were as follows: 1)Radius: bone volume fraction (BT/BV) [estimate 0.17:0.1229(lower)-0.2115 (upper); trabecular number (Tb_N):2.08(2.03-2.12); trabecular thickness (Tb.Th):0.07 (0.07-0.0.08); trabecular separation (Tb.Sp):0.41 (0.38-0.42); cortical thickness (Ct.Th):0.85 (0.76-0.94); cortical porosity (Ct.Po):1.53 (0.63-2.44); total area (Tt.Ar):263.66(-385.3-912.6); total bone density (Tt-vBMD):280.5 (73.1-487.7); Trabecular density (Tb-vBMD):223.6 (47.1-400.09), and cortical density (CT.vBMD):765.9 (389.1-1142.8). 2)Tibia: BT/BV:0.18 (0.17-0.19); Tb_N:2.02 (1.83-2.2); Tb.Th:0.08 (0.80-0.09); Tb.Sp:0.40(0.36-0.44); Ct.Th:1.32(1.26-1.38); Ct.Po:3.15 (1.1-5.2); Tt.Ar:693.1(150.2-1235.8); Tt-vBMD:343.76 (335.5-352.1); Tb-vBMD:223.6 (213.37 (193.5-233.2), and CT.vBMD:894.3 (857.6-931.1). There is overall 'fair' evidence on reporting of results of normative data of HR-pQCT parameters in children, adolescents and/or young adults. However, data are scarce pointing out to the urgent need for standardization of acquisition parameters and guidelines on the use of HR-PQCT in these populations.
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