Evidence map›Paper›PMID 31834838›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2020

Physical and functional interaction sites in cytoplasmic domains of KCNQ1 and KCNE1 channel subunits.

Jerri Chen, Zhenning Liu, John Creagh, Renjian Zheng, Thomas V McDonald

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Functional Profiling ofCirculation. Genomic and precision medicine · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jerri ChenDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, New York.
Zhenning LiuDepartment of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
John CreaghDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, New York.
Renjian ZhengDepartment of Anesthesiology, Columbia University Medical Center, New York, New York.
Thomas V McDonaldDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, New York.ORCID 0000-0002-6075-0888
Albert Einstein College of Medicine · USChina Medical University · CNColumbia University Irving Medical Center · US

Funding

Structure-function Analysis of KCNE Interactions with Cardiac Channels KCNQ1 & HER01HL093440 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MCDONALD, THOMAS V · 2010 to 2013
$1.6M
Structure-function analysis of cardiac KCNQ1 K+ channel interactions with KCNE1F30HL096296 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PRICE, JERRI CHEN · 2009 to 2011
$139k
NHLBI NIH HHS F30 HL096296NHLBI NIH HHS R01 HL093440
6 · The paper itself

Abstract

The cardiac potassium

Indexed as

AnimalsCloning, MolecularCricetinaeCytoplasmDeuteriumElectrophysiological PhenomenaHEK293 CellsHumansHydrogenKCNQ1 Potassium ChannelLong QT SyndromeMutationPlasmidsPotassium Channels, Voltage-GatedDeuteriumHydrogenKCNE1 protein, humanKCNQ1 Potassium ChannelKCNQ1 protein, humanPotassium Channels, Voltage-GatedIKs currentKCNQ1-KCNE1 interactionslong QT syndrome

Identifiers

PMID31834838
PMCPMC7052629
OpenAlexW2996567962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.