SynthesisEuropean radiology2020
Novel imaging techniques to study postmortem human fetal anatomy: a systematic review on microfocus-CT and ultra-high-field MRI.
Synthesis in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- 7.0 Tesla MRI in fetal autopsy: a preliminary exploration of integrating image optimization with clinical practice in a multidisciplinary workflow.Quantitative imaging in medicine and surgery · 2026Article
- Fetal and neonatal postmortem magnetic resonance imaging: indications protocols.Pediatric radiology · 2026Review
- Miscarriage Tissue Research: Still in Its Infancy.Life (Basel, Switzerland) · 2026Review
- CT Morphometric Analysis of Ossification Centres in the Fetal Th12 Vertebra.Brain sciences · 2025Article
- The current state of forensic imaging - recommended radiological tools and international guidelines.International journal of legal medicine · 2025Review
- Micro-computed tomography to visualize preserved vascular architecture in decellularized human vaginal tissue: explorative study.Scientific reports · 2025Article
- Mapping Fetal Brain Development of 10 Weeks' Gestational Age with 9.4T Postmortem MRI and Histologic Sections.AJNR. American journal of neuroradiology · 2025Article
- Brain Structures in a Human Embryo Imaged with MR Microscopy.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025Article
- Imaging the development of the human craniofacial arterial system - an experimental study.Pediatric radiology · 2025Article
- Whole-body non-forensic fetal virtopsy using postmortem magnetic resonance imaging at 7 Tesla vs classical autopsy.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2024Article
- The Cerebrovascular Side of Plasticity: Microvascular Architecture across Health and Neurodegenerative and Vascular Diseases.Brain sciences · 2024Review
- High resolution imaging of human development: shedding light on contrast agents.Neuroradiology · 2024Review
- Development of A Micro-CT Scanner with Dual-Energy Option and Endovascular Contrast Agent Administration Protocol for Fetal and Neonatal Virtual Autopsy.Journal of imaging · 2024Article
- Body weight-based iodinated contrast immersion timing for human fetal postmortem microfocus computed tomography.BJR open · 2024Article
- Post-mortem perinatal imaging: what is the evidence?The British journal of radiology · 2023Review
- Ultra-high-field MRI of postmortem human fetal wrist joints: initial experience.European radiology experimental · 2023Article
- Microfocus computed tomography for fetal postmortem imaging: an overview.Pediatric radiology · 2023Article
- Comparison of postmortem whole-body contrast-enhanced microfocus computed tomography and high-field magnetic resonance imaging of human fetuses.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022Article
- Postmortem Micro-CT of Human Fetal Heart-A Systematic Literature Review.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMRI and CT have been extensively used to study fetal anatomy for research and diagnostic purposes, enabling minimally invasive autopsy and giving insight in human fetal development. Novel (contrast-enhanced) microfocus CT (micro-CT) and ultra-high-field (≥ 7.0 T) MRI (UHF-MRI) techniques now enable micron-level resolution that combats the disadvantages of low-field MRI and conventional CT. Thereby, they might be suitable to study fetal anatomy in high detail and, in time, contribute to the postmortem diagnosis of fetal conditions.
objectives(1) To systematically examine the usability of micro-CT and UHF-MRI to study postmortem human fetal anatomy, and (2) to analyze factors that govern success at each step of the specimen preparation and imaging.
methodMEDLINE and EMBASE were systematically searched to identify publications on fetal imaging by micro-CT or UHF-MRI. Scanning protocols were summarized and best practices concerning specimen preparation and imaging were enumerated.
resultsThirty-two publications reporting on micro-CT and UHF-MRI were included. The majority of the publications focused on imaging organs separately and seven publications focused on whole body imaging, demonstrating the possibility of visualization of small anatomical structures with a resolution well below 100 μm. When imaging soft tissues by micro-CT, the fetus should be stained by immersion in Lugol's staining solution.
conclusionMicro-CT and UHF-MRI are both excellent imaging techniques to provide detailed images of gross anatomy of human fetuses. The present study offers an overview of the current best practices when using micro-CT and/or UHF-MRI to study fetal anatomy for clinical and research purposes. KEY POINTS: • Micro-CT and UHF-MRI can both be used to study postmortem human fetal anatomy for clinical and research purposes. • Micro-CT enables high-resolution imaging of fetal specimens in relatively short scanning time. However, tissue staining using a contrast solution is necessary to enable soft-tissue visualization. • UHF-MRI enables high-resolution imaging of fetal specimens, without the necessity of prior staining, but with the drawback of long scanning time.
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