ArticleThe Journal of cell biology2020
FG-nucleoporins caught in the act of liquid-liquid phase separation.
Article in The Journal of cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets.Signal transduction and targeted therapy · 2025Review
- Deciphering the intrinsically disordered characteristics of the FG-Nups through the lens of polymer physics.Nucleus (Austin, Tex.) · 2024Review
- Phase separation is regulated by post-translational modifications and participates in the developments of human diseases.Heliyon · 2024Review
- Phase Separation: Direct and Indirect Driving Force for High-Order Chromatin Organization.Genes · 2023Review
- Liquid-liquid phase separation as an organizing principle of intracellular space: overview of the evolution of the cell compartmentalization concept.Cellular and molecular life sciences : CMLS · 2022Review
- Structure, Maintenance, and Regulation of Nuclear Pore Complexes: The Gatekeepers of the Eukaryotic Genome.Cold Spring Harbor perspectives in biology · 2022Review
- Local thermodynamics govern formation and dissolution ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Multifunctionality of F-rich nucleoporins.Biochemical Society transactions · 2020Review
- Sis1 potentiates the stress response to protein aggregation and elevated temperature.Nature communications · 2020Article
- Differential Behaviours and Preferential Bindings of Influenza Nucleoproteins on Importins-α.Viruses · 2020Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
The interior of nuclear pore complexes (NPCs) is densely filled with FG-nucleoporins that form a permeability barrier of a still-obscure nature. Celetti et al. (2019. J. Cell Biol.https://doi.org/10.1083/jcb.201907157) now reveal that FG-nucleoporins can undergo liquid-liquid phase separation and form liquid droplets that mimic permeability barrier properties of intact NPCs.
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Registered trials
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