Evidence map›Paper›PMID 31834220›Full record

ArticleJournal of neurologic physical therapy : JNPT2020

Central Drive to the Paretic Ankle Plantarflexors Affects the Relationship Between Propulsion and Walking Speed After Stroke.

Louis N Awad, HaoYuan Hsiao, Stuart A Binder-Macleod

2 registry-linked trialsAbstract read
In one paragraph

Article in Journal of neurologic physical therapy : JNPT, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06459401 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of an Overground Propulsion Neuroprosthesis in Community-dwelling Individuals After Stroke

TypeinterventionalSponsorBoston University Charles River CampusRan2021 to 2022Enrolled10ConditionsStrokeArmsPropulsion Neuroprosthesis
NCT07218107 nacompletednot on this mapstarted 2024, after this paper: background citation

Neurostimulation Exosuit Augmented Training (NEAT) in the Clinic Using a Wearable Propulsion Neuroprosthesis

TypeinterventionalSponsorBoston University Charles River CampusRan2024 to 2024Enrolled4ConditionsStrokeArmsNeurostimulation Exosuit
3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  4. Koopman-Based Model Predictive Control of Functional Electrical Stimulation for Ankle Dorsiflexion and Plantarflexion Assistance.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Louis N AwadDepartment of Physical Therapy and Athletic Training, Boston University, Massachusetts (L.N.A.); Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts (L.N.A.); Department of Kinesiology and Health Education, University of Texas at Austin (H.H.); and Department of Physical Therapy, University of Delaware, Newark (S.A.B.-M.).
HaoYuan Hsiao
Stuart A Binder-Macleod

Funding

Institutional Career DevelopmentKL2TR001411 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MORONE, NATALIA E. · 2015 to 2024
$5.9M
PT/PHD Predoctoral Training Program Diversity SupplementT32HD007490 · NICHD · UNIVERSITY OF DELAWARE · PI DARCY S. REISMAN · 1996 to 2026
$3.7M
Fast Treadmill Training/Functional Electrical Stimulation to Improve WalkingR01NR010786 · NINR · UNIVERSITY OF DELAWARE · PI BINDER-MACLEOD, STUART A. · 2007 to 2011
$2.8M
SCH: Multimodal,Task-Aware Movement Assessment and Control: Clinic to HomeR01AG067394 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI AWAD, LOUIS N, TRON, ROBERTO · 2019 to 2022
$1.2M
NCATS NIH HHS KL2 TR001411NIA NIH HHS R01 AG067394NICHD NIH HHS T32 HD007490NINR NIH HHS R01 NR010786
6 · The paper itself

Abstract

background and purposeThe ankle plantarflexor muscles are the primary generators of propulsion during walking. Impaired paretic plantarflexion is a key contributor to interlimb propulsion asymmetry after stroke. Poststroke muscle weakness may be the result of a reduced force-generating capacity, reduced central drive, or a combination of these impairments. This study sought to elucidate the relationship between the neuromuscular function of the paretic plantarflexor muscles and propulsion deficits across individuals with different walking speeds.

methodsFor 40 individuals poststroke, we used instrumented gait analysis and dynamometry coupled with supramaximal electrostimulation to study the interplay between limb kinematics, the neuromuscular function of the paretic plantarflexors (ie, strength capacity and central drive), propulsion, and walking speed.

resultsThe strength capacity of the paretic plantarflexors was not independently related to paretic propulsion. Reduced central drive to the paretic plantarflexors independently contributed to paretic propulsion deficits. An interaction between walking speed and plantarflexor central drive was observed. Individuals with slower speeds and lower paretic plantarflexor central drive presented with the largest propulsion impairments. Some study participants with low paretic plantarflexor central drive presented with similarly fast speeds as those with near-normal central drive by leveraging a compensatory reliance on nonparetic propulsion. The final model accounted for 86% of the variance in paretic propulsion (R = 0.86, F = 33.10, P < 0.001). DISCUSSION AND

conclusionsIndividuals poststroke have latent paretic plantarflexion strength that they are not able to voluntarily access. The magnitude of central drive deficit is a strong indicator of propulsion impairment in both slow and fast walkers.Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A298).

Indexed as

Stroke RehabilitationAnkleAnkle JointBiomechanical PhenomenaElectric Stimulation TherapyHumansMuscle, SkeletalParesisStrokeWalkingWalking Speed

Identifiers

PMID31834220
PMCPMC8049399

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.