Evidence map›Paper›PMID 31833794›Full record

ArticleEpigenetics

Correlation of Infinium HumanMethylation450K and MethylationEPIC BeadChip arrays in cartilage.

Kathleen Cheung, Marjolein J Burgers, David A Young, Simon Cockell, Louise N Reynard

Open access · hybridAbstract readEvaluation Study
In one paragraph

Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kathleen CheungSkeletal Research Group, Institute of Genetic Medicine, Newcastle University, Central Parkway , Newcastle upon Tyne, UK.ORCID 0000-0002-6449-7517
Marjolein J BurgersSkeletal Research Group, Institute of Genetic Medicine, Newcastle University, Central Parkway , Newcastle upon Tyne, UK.
David A YoungSkeletal Research Group, Institute of Genetic Medicine, Newcastle University, Central Parkway , Newcastle upon Tyne, UK.ORCID 0000-0002-7078-6745
Simon CockellBioinformatics Support Unit, Faculty of Medical Sciences, Newcastle University , Newcastle upon Tyne, UK.
Louise N ReynardSkeletal Research Group, Institute of Genetic Medicine, Newcastle University, Central Parkway , Newcastle upon Tyne, UK.
Newcastle University · GB

Funding

Arthritis Research UKMedical Research Council MR/P020941/1The Dunhill Medical Trust R476/0516Versus Arthritis
6 · The paper itself

Abstract

DNA methylation of CpG sites is commonly measured using Illumina Infinium BeadChip platforms. The Infinium MethylationEPIC array has replaced the Infinium Methylation450K array. The two arrays use the same technology, with the EPIC array assaying almost double the number of sites than the 450K array. In this study, we compare DNA methylation values of shared CpGs of the same human cartilage samples assayed using both platforms. DNA methylation was measured in 21 human cartilage samples using the both 450K and EPIC arrays. Additional matched 450K and EPIC data in whole tumour and whole blood were downloaded from GEO GSE92580 and GSE86833, respectively. Data were processed using the Bioconductor package Minfi. DNA methylation of six CpG sites was validated for the same 21 cartilage samples by pyrosequencing. In cartilage samples, overall sample correlations of methylation values between arrays were high (Pearson's

Indexed as

DNA MethylationCartilageCpG IslandsEpigenomicsHumansOligonucleotide Array Sequence AnalysisSequence Analysis, DNA450K450K vs EPICcartilageDNA methylationEPIC

Identifiers

PMID31833794
PMCPMC7574380
OpenAlexW2998215188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.