Evidence map›Paper›PMID 31833370›Full record

ArticleJournal of natural products2019

Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated

Xiachang Wang, Sherif I Elshahawi, Larissa V Ponomareva, Qing Ye, Yang Liu, Gregory C Copley, James C Hower, Bruce E Hatcher, Madan K Kharel, Steven G Van Lanen and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Molecules (Basel, Switzerland) · 2023
    Article
  2. Review
  3. Nybomycin inhibits both types ofAntimicrobial agents and chemotherapy · 2023
    Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Xiachang WangJiangsu Key Laboratory for Functional Substances of Chinese Medicine , Nanjing University of Chinese Medicine , Nanjing 210023 , People's Republic of China.ORCID 0000-0002-1106-1904
Sherif I ElshahawiDepartment of Biomedical and Pharmaceutical Sciences , Chapman University School of Pharmacy , Irvine , California 92618 , United States.ORCID 0000-0003-1879-1552
Larissa V Ponomareva
Qing YeMarkey Cancer Center, Department of Pharmacology and Nutritional Sciences, College of Medicine , University of Kentucky , Lexington , Kentucky 40536 , United States.
Yang Liu
Gregory C CopleyCenter for Applied Energy Research , University of Kentucky , Lexington , Kentucky 40511 , United States.
James C HowerCenter for Applied Energy Research , University of Kentucky , Lexington , Kentucky 40511 , United States.ORCID 0000-0003-4694-2776
Bruce E HatcherDivision of Water , Kentucky Energy and Environment Cabinet , 2642 Russellville Road , Bowling Green , Kentucky 42101 , United States.
Madan K KharelSchool of Pharmacy , University of Maryland Eastern Shore , Princess Anne , Maryland 21853 , United States.
Steven G Van LanenORCID 0000-0003-1539-2732
Qing-Bai SheMarkey Cancer Center, Department of Pharmacology and Nutritional Sciences, College of Medicine , University of Kentucky , Lexington , Kentucky 40536 , United States.
S Randal Voss
Jon S ThorsonORCID 0000-0002-7148-0721
Khaled A ShaabanORCID 0000-0001-7638-4942
University of Kentucky · USChapman University · USKentucky Cabinet For Health and Family Services · USNanjing University of Chinese Medicine · CNUniversity of Maryland Eastern Shore · US

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3M
Targeting Translation Dependence in Colorectal Cancer ProgressionR01CA175105 · NCI · UNIVERSITY OF KENTUCKY · PI SHE, QING-BAI · 2013 to 2024
$3.3M
Developing Regeneration Resources for a Model AmphibianR24OD021479 · OD · UNIVERSITY OF KENTUCKY · PI THORSON, JON SCOTT, VOSS, STEPHEN RANDAL · 2016 to 2019
$2.3M
Platform technologies for understanding and exploiting methylationR01GM115261 · NIGMS · UNIVERSITY OF KENTUCKY · PI PHILLIPS, GEORGE NEAL, THORSON, JON SCOTT · 2016 to 2019
$2.2M
Natural product-based modulators of 4E-BP1 phosphorylationR01CA203257 · NCI · UNIVERSITY OF KENTUCKY · PI SHE, QING-BAI, THORSON, JON SCOTT · 2016 to 2020
$1.9M
NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR001998NCI NIH HHS R01 CA175105NCI NIH HHS R01 CA203257NIGMS NIH HHS R01 GM115261NIH HHS R24 OD021479
6 · The paper itself

Abstract

We report the isolation and characterization of three new nybomycins (nybomycins B-D,

Indexed as

Anti-Bacterial AgentsAntifungal AgentsCell Line, TumorDrug Screening Assays, AntitumorGram-Positive BacteriaHumansMolecular StructureQuinolonesSpectrum AnalysisStreptomycesAnti-Bacterial AgentsAntifungal AgentsnybomycinQuinolones

Identifiers

PMID31833370
PMCPMC7084111
OpenAlexW2996312596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.