Evidence map›Paper›PMID 31833153›Full record

ArticleProtein science : a publication of the Protein Society2020

Glutaminyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization, structure, and development as a screening platform.

Yaritza Escamilla, Casey A Hughes, Jan Abendroth, David M Dranow, Samantha Balboa, Frank B Dean, James M Bullard

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Architecture ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Crystal structure of glutamyl-tRNA synthetase from Helicobacter pylori.Acta crystallographica. Section F, Structural biology communications · 2024
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yaritza EscamillaUniversity of Texas Rio Grande Valley, Edinburg, Texas.
Casey A HughesUniversity of Texas Rio Grande Valley, Edinburg, Texas.
Jan AbendrothSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington.
David M DranowSeattle Structural Genomics Center for Infectious Disease, Seattle, Washington.
Samantha BalboaUniversity of Texas Rio Grande Valley, Edinburg, Texas.
Frank B DeanUniversity of Texas Rio Grande Valley, Edinburg, Texas.
James M BullardUniversity of Texas Rio Grande Valley, Edinburg, Texas.ORCID 0000-0002-3068-3717
The University of Texas Rio Grande Valley · USCenter for Infectious Disease Research · US

Funding

UTPA RISE Undergraduate Training ProgramR25GM100866 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI DEARTH, ROBERT KEITH, PARSONS, JASON · 2012 to 2016
$1.8M
Construction of a Protein Synthesis System from Pseudomonas aeruginosa for Screening for Antibacterial CandidatesSC3GM098173 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI BULLARD, JAMES M · 2012 to 2019
$861k
NIAID NIH HHS HHSN272201700059CNIGMS NIH HHS 1R25GM100866NIGMS NIH HHS 1SC3GM098173NIGMS NIH HHS R25 GM100866NIGMS NIH HHS SC3 GM098173
6 · The paper itself

Abstract

Pseudomonas aeruginosa has a high potential for developing resistance to multiple antibiotics. The gene (glnS) encoding glutaminyl-tRNA synthetase (GlnRS) from P. aeruginosa was cloned and the resulting protein characterized. GlnRS was kinetically evaluated and the K

Indexed as

Amino Acyl-tRNA SynthetasesAnti-Bacterial AgentsDose-Response Relationship, DrugDrug Evaluation, PreclinicalEnzyme InhibitorsKineticsMicrobial Sensitivity TestsMolecular StructurePseudomonas aeruginosaAmino Acyl-tRNA SynthetasesAnti-Bacterial AgentsEnzyme Inhibitorsglutaminyl-tRNA synthetaseaminoacyl-tRNA synthetaseantibioticsdrug discoveryglutaminyl-tRNA synthetaseprotein synthesisPseudomonas aeruginosa

Identifiers

PMID31833153
PMCPMC7096721
OpenAlexW2995418381

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.