Observational studyEuropean journal of clinical pharmacology2020
Personalising drug safety-results from the multi-centre prospective observational study on Adverse Drug Reactions in Emergency Departments (ADRED).
Observational study in European journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 28 citations in OpenAlex.
- Inhalation therapies in COPD - adverse drug reactions impact on emergency department presentations.European journal of clinical pharmacology · 2023Trial
- The quantitative impact of metabolism-inhibiting drugs on the occurrence of adverse drug reactions-A backward selection approach.British journal of clinical pharmacology · 2026Article
- Influence of drugs on blood potassium levels in older, multi-medicated patients - results of two cohort studies focusing on adverse drug reactions.BMC geriatrics · 2026Article
- Association of high risk of liver fibrosis in patients with serious outcomes of adverse drug reactions.European journal of clinical pharmacology · 2026Article
- Implementing a clinical pharmacy intervention for older adult inpatients with chronic non-cancer pain: a feasibility study.International journal of clinical pharmacy · 2026Article
- Implied ADR-Admissions: A Cohort Study Introducing a Novel Administrative Data Approach for Identifying Drug-Related Hospitalisations.Drug safety · 2026Article
- [Recording medication errors in Germany-a workshop report].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Article
- Machine learning risk prediction models for medication harm in hospitalised adult patients.Therapeutic advances in drug safety · 2026Article
- Comparative Analysis of Drugs Frequently Suspected of Causing Adverse Drug Reactions Reported via the Spontaneous Reporting System Versus in a Prospective Multicentre Cohort Study in Hospital Emergency Departments.Journal of clinical medicine · 2025Article
- Drug-Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources.Clinical pharmacology and therapeutics · 2025Article
- Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review.Journal of medical Internet research · 2024Article
- Dealing with adverse drug reactions in the context of polypharmacy using regression models.Scientific reports · 2024Article
- Serious gaming as potential training tool for recognition of adverse drug reactions: side-effect exposure-medical education (SeeMe).European journal of clinical pharmacology · 2024Article
- Assessment of Substrate Status of Drugs Metabolized by Polymorphic Cytochrome P450 (CYP) 2 Enzymes: An Analysis of a Large-Scale Dataset.Biomedicines · 2024Article
- The influence of age, gender and pharmacogenetic profiles on the perspective on medicines in the German EMPAR study.PloS one · 2024Observational
- [Adverse drug reactions as cause of nonspecific symptoms in patients in the emergency department].Die Anaesthesiologie · 2023Review
- Which Adverse Events and Which Drugs Are Implicated in Drug-Related Hospital Admissions? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Article
- Emergency Department Visits Due to Dyspnea: Association with Inhalation Therapy in COPD and Cases with Adverse Drug Reactions.International journal of chronic obstructive pulmonary disease · 2022Article
- CYP2D6 in the Brain: Potential Impact on Adverse Drug Reactions in the Central Nervous System-Results From the ADRED Study.Frontiers in pharmacology · 2021Article
- The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study.British journal of clinical pharmacology · 2020Observational
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
purposeAdverse drug reactions (ADR) account for 5 to 7% of emergency department (ED) consultations. We aimed to assess medication risk profiles for ADRs leading to ED visits.
methodsWe analysed medication intake and patient demographics in a prospective multi-centre observational study collecting ADR cases in four large EDs in Germany. Odds ratios (OR) were calculated to relate drug classes taken to those suspicious for an ADR after a causality assessment.
resultsA total of 2215 cases of ED visits due to ADRs were collected. The median age of the cohort was 73 years; in median, six co-morbidities and an intake of seven drugs were documented. Antineoplastic/immunomodulating agents had the highest OR for being suspected for an ADR (OR 20.45, 95% CI 14.54-28.77), followed by antithrombotics (OR 2.94, 95% CI 2.49-3.47), antibiotics (OR 2.65, 95% CI 1.78-3.95), systemic glucocorticoids (OR 2.43, 95% CI 1.54-3.82) and drugs affecting the central nervous system (CNS), such as antipsychotics (OR 2.36, 95% CI 1.46-3.81), antidepressants (OR 2.10, 95% CI 1.57-2.83), antiparkinsonian medication (OR 2.11, 95% CI 1.15-3.84), opioids (OR 1.79, 95% CI 1.26-2.54) and non-opioid analgesics (OR 1.32, 95% CI 1.01-1.72).
conclusionsPatients experiencing ADRs leading to ED visits are commonly old, multi-morbid and multi-medicated. CNS drugs may be more relevant than prior expected. With calculating ORs, we could replicate involvement of antineoplastic agents, antithrombotics, antibiotics, systemic glucocorticoids and non-opioid analgesics as frequently suspected for ADRs in EDs.
trial registrationDRKS-ID: DRKS00008979.
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