ReviewEnvironmental management2020
Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper.
Review in Environmental management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 109 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 497 citations in OpenAlex.
- Guaiazulene-Based 2‑Hydrazinylpyridine Probe (ACS omega · 2026Article
- BODIPY with Solvent Polarity and Viscosity Sensitivity for Colorimetric and Fluorescent dual-mode Detection of CuJournal of fluorescence · 2026Article
- Copper Compounds: A Narrative and Regulatory Review of Agricultural Uses, Risks, and Environmental Assessment.Toxics · 2026Review
- Tomato-derived carbon quantum dots: composition-driven structure and copper sensing potential.Scientific reports · 2026Article
- Assessment of Dermally Bioaccessible Elements by Sweat-Simulated Extraction: Analytical Approach and Application to Tattoo Inks.Molecules (Basel, Switzerland) · 2026Article
- Review
- Chitosan-Based Adsorbents: A Versatile Platform for the Removal of Arsenate and Copper Ions from Water.Nanomaterials (Basel, Switzerland) · 2026Review
- Substituent-Tuned Benzoyl Thiourea Chemosensors for Selective Fluorescence Quenching of CuJournal of fluorescence · 2026Article
- Assessment of water quality in moatize, mozambique: possible human health risks from coal mining and use.Environmental geochemistry and health · 2026Article
- Butylated Hydroxy Anisole-Based 1,2,3-Triazole Probe for Fluorescent Recognition of Cu(II), Fe(III), with Masked Sensing of Ce(III).Journal of fluorescence · 2026Article
- Ecological and human health risks of potentially toxic elements across land uses in a dust-prone region of Central Iran.Scientific reports · 2026Article
- Essential minerals and risk of pancreatic diseases: a large-scale prospective cohort study.Frontiers in nutrition · 2026Article
- Synthesis, application and modelling of spherical magnetic silicon poly-N,N'-methylenebisacrylamide nanocomposite for effective copper removal from water.Scientific reports · 2025Article
- Heavy Metals Detection via Plastic-Waste-Derived Carbon Dots: Review.Journal of fluorescence · 2025Review
- Selenium Supplementation Mitigates Copper-Induced Systemic Toxicity via Transcriptomic Reprogramming and Redox Homeostasis in Mice.Foods (Basel, Switzerland) · 2025Article
- Electrochemical Detection of Multiple Heavy Metal Ions Using a Hybrid Nanocomposite of a Metal-Organic Framework and Cellulose Nanocrystal-PEDOT:PSS.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Application of chitosan/graphene and chitosan/graphene oxide composites for removal of Cu and Pb.Scientific reports · 2025Article
- Chronic Copper Overload Triggers Inflammation in Mesenteric PVAT Alongside Changes in Renin-Angiotensin System-Related Pathways.Nutrients · 2025Article
- The Socio-Environmental Impact in the Adjacent Settlements of a Former Foundry.International journal of environmental research and public health · 2025Article
- Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decades of study indicate that copper oral exposures are typically not a human health concern. Ingesting high levels of soluble copper salts can cause acute gastrointestinal symptoms and, in uncommon cases, liver toxicity in susceptible individuals with repeated exposure. This focused toxicological review evaluated the current literature since the last comprehensive reviews (2007-2010). Our review identified limitations in the existing United States and international guidance for determining an oral reference dose (RfD) for essential metals like copper. Instead, an alternative method using categorical regression analysis to develop an optimal dose that considers deficiency, toxicity, and integrates information from human and animal studies was reviewed for interpreting an oral RfD for copper. We also considered subchronic or chronic toxicity from genetic susceptibility to copper dysregulation leading to rare occurrences of liver and other organ toxicity with elevated copper exposure. Based on this approach, an oral RfD of 0.04 mg Cu/kg/day would be protective of acute or chronic toxicity in adults and children. This RfD is also protective for possible genetic susceptibility to elevated copper exposure and allows for background dietary exposures. This dose is not intended to be protective of patients with rare genetic disorders for copper sensitivity within typical nutritional intake ranges, nor is it protective for those with excessive supplement intake. Less soluble mineral forms of copper in soil have reduced bioavailability as compared with more soluble copper in water and diet, which should be considered in using this RfD for risk assessments of copper.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.