Evidence map›Paper›PMID 31832697›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2020

Machine learning methods are comparable to logistic regression techniques in predicting severe walking limitation following total knee arthroplasty.

Yong-Hao Pua, Hakmook Kang, Julian Thumboo, Ross Allan Clark, Eleanor Shu-Xian Chew, Cheryl Lian-Li Poon, Hwei-Chi Chong, Seng-Jin Yeo

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Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Machine learning in knee arthroplasty: specific data are key-a systematic review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022
    Pooled it
  4. Joint-specific measures improve risk adjustment in total knee arthroplasty: A machine learning approach.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
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  10. Global mapping of institutional and hospital-based (Level II-IV) arthroplasty registries: a scoping review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yong-Hao PuaDepartment of Physiotherapy, Singapore General Hospital, Singapore, Singapore. pua.yong.hao@sgh.com.sg.ORCID http://orcid.org/0000-0003-2313-9665
Hakmook KangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Julian ThumbooDepartment of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.
Ross Allan ClarkResearch Health Institute, University of the Sunshine Coast, Sunshine Coast, Australia.
Eleanor Shu-Xian ChewDepartment of Physiotherapy, Singapore General Hospital, Singapore, Singapore.
Cheryl Lian-Li PoonDepartment of Physiotherapy, Singapore General Hospital, Singapore, Singapore.
Hwei-Chi ChongDepartment of Physiotherapy, Changi General Hospital, Singapore, Singapore.
Seng-Jin YeoDepartment of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMachine-learning methods are flexible prediction algorithms with potential advantages over conventional regression. This study aimed to use machine learning methods to predict post-total knee arthroplasty (TKA) walking limitation, and to compare their performance with that of logistic regression.

methodsFrom the department's clinical registry, a cohort of 4026 patients who underwent elective, primary TKA between July 2013 and July 2017 was identified. Candidate predictors included demographics and preoperative clinical, psychosocial, and outcome measures. The primary outcome was severe walking limitation at 6 months post-TKA, defined as a maximum walk time ≤ 15 min. Eight common regression (logistic, penalized logistic, and ordinal logistic with natural splines) and ensemble machine learning (random forest, extreme gradient boosting, and SuperLearner) methods were implemented to predict the probability of severe walking limitation. Models were compared on discrimination and calibration metrics.

resultsAt 6 months post-TKA, 13% of patients had severe walking limitation. Machine learning and logistic regression models performed moderately [mean area under the ROC curves (AUC) 0.73-0.75]. Overall, the ordinal logistic regression model performed best while the SuperLearner performed best among machine learning methods, with negligible differences between them (Brier score difference, < 0.001; 95% CI [- 0.0025, 0.002]).

conclusionsWhen predicting post-TKA physical function, several machine learning methods did not outperform logistic regression-in particular, ordinal logistic regression that does not assume linearity in its predictors. LEVEL OF EVIDENCE: Prognostic level II.

Indexed as

Machine LearningMobility LimitationWalkingAgedArthroplasty, Replacement, KneeFemaleHumansLogistic ModelsMaleMiddle AgedPostoperative ComplicationsPrognosisRegistriesTreatment OutcomeAlgorithmsArthroplastyArtificial intelligenceKneeMachine learningPredictionReplacement

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.