ArticleCerebral cortex (New York, N.Y. : 1991)2020
Differential Effects of Open- and Closed-Loop Intracortical Microstimulation on Firing Patterns of Neurons in Distant Cortical Areas.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mapping of subthalamic nucleus using microelectrode recordings during deep brain stimulation.Scientific reports · 2020Trial
- Advancing neuroengineering with Neuromorphic Twins.Nature communications · 2026Review
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network.Nature communications · 2024Article
- Personalized strategies of neurostimulation: from static biomarkers to dynamic closed-loop assessment of neural function.Frontiers in neuroscience · 2024Review
- Innova4Health: an integrated approach for prevention of recurrence and personalized treatment of Major Depressive Disorder.Frontiers in artificial intelligence · 2024Article
- Excitatory-inhibitory recurrent dynamics produce robust visual grids and stable attractors.Cell reports · 2022Article
- Neuromorphic-Based Neuroprostheses for Brain Rewiring: State-of-the-Art and Perspectives in Neuroengineering.Brain sciences · 2022Review
- The impact of closed-loop intracortical stimulation on neural activity in brain-injured, anesthetized animals.Bioelectronic medicine · 2022Article
- Activity dependent stimulation increases synaptic efficacy in spared pathways in an anesthetized rat model of spinal cord contusion injury.Restorative neurology and neuroscience · 2022Article
- LFP Analysis of Brain Injured Anesthetized Animals Undergoing Closed-Loop Intracortical Stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2022Article
- Entrainment of Network Activity by Closed-Loop Microstimulation in Healthy Ambulatory Rats.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- SANTIA: a Matlab-based open-source toolbox for artifact detection and removal from extracellular neuronal signals.Brain informatics · 2021Article
- Injecting Information into the Mammalian Cortex: Progress, Challenges, and Promise.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Intracortical microstimulation can be used successfully to modulate neuronal activity. Activity-dependent stimulation (ADS), in which action potentials recorded extracellularly from a single neuron are used to trigger stimulation at another cortical location (closed-loop), is an effective treatment for behavioral recovery after brain lesion, but the related neurophysiological changes are still not clear. Here, we investigated the ability of ADS and random stimulation (RS) to alter firing patterns of distant cortical locations. We recorded 591 neuronal units from 23 Long-Evan healthy anesthetized rats. Stimulation was delivered to either forelimb or barrel field somatosensory cortex, using either RS or ADS triggered from spikes recorded in the rostral forelimb area (RFA). Both RS and ADS stimulation protocols rapidly altered spike firing within RFA compared with no stimulation. We observed increase in firing rates and change of spike patterns. ADS was more effective than RS in increasing evoked spikes during the stimulation periods, by producing a reliable, progressive increase in stimulus-related activity over time and an increased coupling of the trigger channel with the network. These results are critical for understanding the efficacy of closed-loop electrical microstimulation protocols in altering activity patterns in interconnected brain networks, thus modulating cortical state and functional connectivity.
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Registered trials
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