Evidence map›Paper›PMID 31832627›Full record

ArticleCrohn's & colitis 3602019

An Autoimmune Protocol Diet Improves Patient-Reported Quality of Life in Inflammatory Bowel Disease.

Anita Chandrasekaran, Shauna Groven, James D Lewis, Susan S Levy, Caroline Diamant, Emily Singh, Gauree Gupta Konijeti

Open access · goldAbstract read
In one paragraph

Article in Crohn's & colitis 360, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Early life factors, diet and microbiome, and risk of inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2025
    Article
  7. Review
  8. Article
  9. Dietary patterns, beliefs and behaviours among individuals with inflammatory bowel disease: a cross-sectional study.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Anita ChandrasekaranDivision of Gastroenterology, Scripps Clinic, La Jolla, CA.
Shauna GrovenSchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA.
James D LewisCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Susan S LevySchool of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA.
Caroline DiamantDivision of Gastroenterology, Scripps Clinic, La Jolla, CA.
Emily SinghDivision of Gastroenterology, Scripps Clinic, La Jolla, CA.
Gauree Gupta KonijetiDivision of Gastroenterology, Scripps Clinic, La Jolla, CA.ORCID 0000-0003-4221-4579
Scripps Clinic · USSan Diego State University · USUniversity of Pennsylvania · US

Funding

SCRIPPS TRANSLATIONAL SCIENCE INSTITUTE (UL1)UL1RR025774 · NCRR · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2008 to 2011
$16.3M
Test-Treat strategy to prevent ulcerative colitis relapseK24DK078228 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEWIS, JAMES D · 2007 to 2016
$1.9M
NCRR NIH HHS UL1 RR025774NIDDK NIH HHS K24 DK078228
6 · The paper itself

Abstract

backgroundPrior studies suggest dietary modification may improve clinical response or remission rates in patients with inflammatory bowel disease (IBD). Our aim was to examine whether an autoimmune protocol diet improves quality of life in patients with active Crohn disease (CD) and ulcerative colitis (UC).

methodsWe conducted an uncontrolled clinical trial of the autoimmune protocol diet in adult patients with active IBD (Harvey-Bradshaw Index ≥ 5 for CD or partial Mayo score ≥ 3 for UC, and erosions/ulcers on endoscopy and/or elevated fecal calprotectin). The dietary intervention consisted of a 6-week elimination phase, followed by a 5-week maintenance phase. Short Inflammatory Bowel Disease Questionnaire (SIBDQ) was completed at baseline, and weeks 3, 6, 9, and 11.

resultsThe final cohort included 6 UC and 9 CD participants. Mean SIBDQ score improved significantly from baseline (46.5) to weeks 3 (54.0,

conclusionsDietary modification can improve quality of life as early as week 3 in patients with active IBD. Larger randomized controlled trials are needed to examine dietary interventions in IBD.

Indexed as

autoimmune protocolCrohn diseasedietinflammatory bowel diseasequality of lifeulcerative colitis

Identifiers

PMID31832627
PMCPMC6892563
OpenAlexW2964895305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.