Evidence map›Paper›PMID 31832620›Full record

ArticleEClinicalMedicine2019

Hypoxaemia in hospitalised children and neonates: A prospective cohort study in Nigerian secondary-level hospitals.

Hamish Graham, Ayobami A Bakare, Adejumoke I Ayede, Oladapo B Oyewole, Amy Gray, David Peel, Barbara McPake, Eleanor Neal, Shamim A Qazi, Rasa Izadnegahdar and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 7 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 7 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Hamish GrahamDepartment of Paediatrics, University College Hospital, Ibadan, Nigeria.
Ayobami A BakareDepartment of Paediatrics, University College Hospital, Ibadan, Nigeria.
Adejumoke I AyedeDepartment of Paediatrics, University College Hospital, Ibadan, Nigeria.
Oladapo B OyewoleDepartment of Paediatrics, University College Hospital, Ibadan, Nigeria.
Amy GrayCentre for International Child Health, University of Melbourne, MCRI, Royal Children's Hospital, Parkville, Australia.
David PeelAshdown Consultants, Hartfield, England.
Barbara McPakeNossal Institute of Global Health, University of Melbourne, Parkville, Australia.
Eleanor NealCentre for International Child Health, University of Melbourne, MCRI, Royal Children's Hospital, Parkville, Australia.
Shamim A QaziDepartment of Maternal, Newborn, Child and Adolescent Health, World Health Organization, Geneva, Switzerland.
Rasa IzadnegahdarBill and Melinda Gates Foundation, Seattle, USA.
Trevor DukeCentre for International Child Health, University of Melbourne, MCRI, Royal Children's Hospital, Parkville, Australia.
Adegoke G FaladeDepartment of Paediatrics, University College Hospital, Ibadan, Nigeria.
Royal Children's Hospital · AUUniversity College Hospital, Ibadan · NGUniversity of Ibadan · NGGates Foundation · USThe University of Melbourne · AUWorld Health Organization · CH

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundHypoxaemia is a common complication of pneumonia and a major risk factor for death, but less is known about hypoxaemia in other common conditions. We evaluated the epidemiology of hypoxaemia and oxygen use in hospitalised neonates and children in Nigeria.

methodsWe conducted a prospective cohort study among neonates and children (<15 years of age) admitted to 12 secondary-level hospitals in southwest Nigeria (November 2015-November 2017) using data extracted from clinical records (documented during routine care). We report summary statistics on hypoxaemia prevalence, oxygen use, and clinical predictors of hypoxaemia. We used generalised linear mixed-models to calculate relative odds of death (hypoxaemia vs not).

findingsParticipating hospitals admitted 23,926 neonates and children during the study period. Pooled hypoxaemia prevalence was 22.2% (95%CI 21.2-23.2) for neonates and 10.2% (9.7-10.8) for children. Hypoxaemia was common among children with acute lower respiratory infection (28.0%), asthma (20.4%), meningitis/encephalitis (17.4%), malnutrition (16.3%), acute febrile encephalopathy (15.4%), sepsis (8.7%) and malaria (8.5%), and neonates with neonatal encephalopathy (33.4%), prematurity (26.6%), and sepsis (21.0%). Hypoxaemia increased the adjusted odds of death 6-fold in neonates and 7-fold in children. Clinical signs predicted hypoxaemia poorly, and their predictive ability varied across ages and conditions. Hypoxaemic children received oxygen for a median of 2-3 days, consuming ∼3500 L of oxygen per admission.

interpretationHypoxaemia is common in respiratory and non-respiratory acute childhood illness and increases the risk of death substantially. Given the limitations of clinical signs, pulse oximetry is an essential tool for detecting hypoxaemia, and should be part of the routine assessment of all hospitalised neonates and children.

Indexed as

AfricaChildHypoxaemiaNeonateNigeriaOxygenPulse oximetry

Identifiers

PMID31832620
PMCPMC6890969
OpenAlexW2981561535

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.