Evidence map›Paper›PMID 31832618›Full record

ArticleEClinicalMedicine2019

Type 2 diabetes complications and comorbidity in Sub-Saharan Africans.

Kenneth Ekoru, Ayo Doumatey, Amy R Bentley, Guanjie Chen, Jie Zhou, Daniel Shriner, Olufemi Fasanmade, Godfrey Okafor, Benjamin Eghan, Kofi Agyenim-Boateng and 11 more

Abstract read
In one paragraph

Article in EClinicalMedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  20. Healthcare workers' views on type 2 diabetes mellitus management at selected clinics in Mthatha.African journal of primary health care & family medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kenneth EkoruCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Ayo DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Guanjie ChenCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Jie ZhouCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Daniel ShrinerCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Olufemi FasanmadeUniversity of Lagos, Lagos, Nigeria.
Godfrey OkaforUniversity of Nigeria Teaching Hospital, Enugu, Nigeria.
Benjamin EghanUniversity of Science and Technology, Kumasi, Ghana.
Kofi Agyenim-BoatengUniversity of Science and Technology, Kumasi, Ghana.
Jokotade AdeleyeUniversity of Ibadan, Ibadan, Nigeria.
Williams BalogunUniversity of Ibadan, Ibadan, Nigeria.
Albert AmoahUniversity of Ghana Medical School, Accra, Ghana.
Joseph AcheampongUniversity of Science and Technology, Kumasi, Ghana.
Thomas JohnsonUniversity of Lagos, Lagos, Nigeria.
Johnnie OliUniversity of Nigeria Teaching Hospital, Enugu, Nigeria.
Clement AdebamowoInstitute of Human Virology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Francis CollinsNational Institutes of Health, Bethesda, MD, USA.
Georgia DunstonNational Human Genome Center at Howard University, Washington, DC, USA.
Adebowale AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Charles RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Funding

Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
MINORITY INTERNATIONAL RESEARCH TRAINING GRANTT37TW000041 · FIC · HOWARD UNIVERSITY · PI ADAMS-CAMPBELL, LUCILE L · 1993 to 1998
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FIC NIH HHS T37 TW000041Intramural NIH HHS ZIA HG200362
6 · The paper itself

Abstract

backgroundContext-specific evidence of the spectrum of type 2 diabetes (T2D) burden is essential for setting priorities and designing interventions to reduce associated morbidity and mortality. However, there are currently limited data on the burden of T2D complications and comorbidity in sub-Saharan Africa (SSA).

methodsT2D complications and comorbidities were assessed in 2,784 participants with diabetes enrolled from tertiary health centres and contextualised in 3,209 individuals without diabetes in Nigeria, Ghana and Kenya. T2D complications and comorbidities evaluated included cardiometabolic, ocular, neurological and renal characteristics.

findingsThe most common complications/comorbidities among the T2D participants were hypertension (71%; 95% CI 69-73), hyperlipidaemia (34%; 95% CI 32-36), and obesity (27%; 95% CI 25-29). Additionally, the prevalence of cataracts was 32% (95% CI 30-35), diabetic retinopathy 15% (95% CI 13-17), impaired renal function 13% (95% CI 12-15), and erectile dysfunction (in men) 35% (95% CI 32-38). T2D population-attributable fraction for these comorbidities ranged between 6 and 64%.

interpretationThe burden of diabetes complications and comorbidity is substantial in SSA highlighting the urgent need for innovative public health strategies that prioritise promotion of healthy lifestyles for prevention and early detection of T2D. Also needed are strategies to strengthen health care system capacities to provide treatment and care for diabetes complications.

Indexed as

Co-morbidityComplicationsEpidemiologySub-Sahara AfricaType 2 Diabetes

Identifiers

PMID31832618
PMCPMC6890980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.