Evidence map›Paper›PMID 31832595›Full record

ArticleBJS open2019

Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model.

R A Inglin, L E Brügger, D Candinas, B S Harrison, D Eberli

Open access · goldAbstract read
In one paragraph

Article in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

R A InglinLaboratory of Tissue Engineering and Stem Cell Therapy, Department of Urology University Hospital Zurich Zurich Switzerland.ORCID 0000-0002-7298-2678
L E BrüggerLaboratory of Tissue Engineering and Stem Cell Therapy, Department of Urology University Hospital Zurich Zurich Switzerland.
D CandinasDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital University of Bern Bern Switzerland.
B S HarrisonWake Forest Institute for Regenerative Medicine Wake Forest University, Medical Center Boulevard Winston-Salem North Carolina USA.
D EberliLaboratory of Tissue Engineering and Stem Cell Therapy, Department of Urology University Hospital Zurich Zurich Switzerland.
University of Bern · CHForest Institute · USUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anastomotic leak remains a significant cause of morbidity and mortality after colorectal surgery. Among multiple risk factors considered, hypoxia-ischaemia is considered to be a primary cause of intestinal anastomotic leakage. The aim of this experimental study was to assess safety, usability for surgical tasks, and efficacy of a newly developed oxygen-producing suture material in the healing of colonic anastomoses under critical conditions. Methods: An oxygen-producing suture material was produced that is capable of releasing oxygen directly into the surrounding tissue. Off-the-shelf sutures loaded with calcium peroxide nano-crystals and covered with poly(d,l-lactide-co-glycolide) were assessed Results: Conclusion: Oxygen-producing suture material increased tissue oxygen saturation and mechanical stability of colonic anastomosis in a rat model.

Indexed as

SuturesAnastomosis, SurgicalAnastomotic LeakAnimalsColonDisease Models, AnimalHumansMaleOxygenPeroxidesPolylactic Acid-Polyglycolic Acid CopolymerRatscalcium peroxideOxygenPeroxidesPolylactic Acid-Polyglycolic Acid Copolymer

Identifiers

PMID31832595
PMCPMC6887904
OpenAlexW2978732281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.