Evidence map›Paper›PMID 31832591›Full record

ArticleBJS open2019

Cytotoxicity and effect on wound re-epithelialization after topical administration of tranexamic acid.

T A Eikebrokk, B S Vassmyr, K Ausen, C Gravastrand, O Spigset, B Pukstad

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJS open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04541303 (Randomized Study on the Topical Application of Tranexamic Acid to Wound Bed for Hemostasis in the Setting Granulating Wounds Following Mohs Micrographic Surgery), which is not on this map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04541303 early_phase1completednot on this mapstarted 2020, after this paper: background citation

Randomized Study on the Topical Application of Tranexamic Acid to Wound Bed for Hemostasis in the Setting Granulating Wounds Following Mohs Micrographic Surgery

TypeinterventionalSponsorUniversity of Missouri-ColumbiaRan2020 to 2021Enrolled124ConditionsPostoperative Wound HaemorrhageArmsTranexamic acid, normal saline
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  4. Trial
  5. Review
  6. Article
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  13. Efficacy of topicalWorld journal of clinical cases · 2021
    Article
  14. A Systematic Review of Tranexamic Acid in Plastic Surgery: What's New?Plastic and reconstructive surgery. Global open · 2021
    Article
  15. Article
  16. Clinical use of tranexamic acid: evidences and controversies.Brazilian journal of anesthesiology (Elsevier)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

T A EikebrokkFaculty of Medicine Norwegian University of Science and Technology Trondheim Norway.
B S VassmyrFaculty of Medicine Norwegian University of Science and Technology Trondheim Norway.
K AusenDepartment of Circulation and Medical Imaging Norwegian University of Science and Technology Trondheim Norway.ORCID 0000-0001-6247-5608
C GravastrandDepartment of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway.
O SpigsetDepartment of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway.
B PukstadDepartment of Clinical and Molecular Medicine Norwegian University of Science and Technology Trondheim Norway.
Norwegian University of Science and Technology · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is off-label. Surgeons lack guidelines regarding safe topical dosages and modes of administration. The effects of topical TXA on skin cells and wound healing are unknown. This study investigated whether topical TXA might be cytotoxic or affect wound re-epithelialization. Methods: Human keratinocytes and fibroblast cell cultures and an Results: In cell culture, toxicity from chronic exposure was associated with increasing concentration and exposure time. Limited exposure to TXA did not cause significant cytotoxicity even at high concentrations. Re-epithelialization was completely absent in wounds chronically exposed to TXA concentrations of 25 mg/ml or above, and 50-100 mg/ml induced epidermolysis of normal epithelium, possibly by a non-toxic mechanism. Wound re-epithelialization was slightly delayed, but not impaired, by limited exposure to 100 mg/ml or chronic exposure to 6·25 mg/ml. Conclusion: Although short exposure to even high concentrations of topical TXA seems well tolerated

Indexed as

Administration, TopicalAntifibrinolytic AgentsBlood Loss, SurgicalCell Culture TechniquesCell LineDose-Response Relationship, DrugFibroblastsHemostasis, SurgicalHemostatic TechniquesHumansKeratinocytesRe-EpithelializationSkinSurgical WoundTime FactorsToxicity Tests, AcuteAntifibrinolytic AgentsTranexamic Acid

Identifiers

PMID31832591
PMCPMC6887721
OpenAlexW2977211516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.