Evidence map›Paper›PMID 31832521›Full record

ArticleGenes & diseases2019

Identification and characterization of the cellular subclones that contribute to the pathogenesis of mantle cell lymphoma.

Junling Tang, Li Zhang, Tiejun Zhou, Zhiwei Sun, Liangsheng Kong, Li Jing, Hongyun Xing, Hongyan Wu, Yongli Liu, Shixia Zhou and 14 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Goodbye flat lymphoma biology.FEBS letters · 2025
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Junling TangLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Li ZhangThe Affiliated Stomatology Hospital of Southwest Medical University, 2 Jiangyangnan Rd, Luzhou, 646000, China.
Tiejun ZhouDepartment of Pathology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Zhiwei SunLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Liangsheng KongLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Li JingDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Hongyun XingDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Hongyan WuDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Yongli LiuLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Shixia ZhouLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Jingyuan LiLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Mei ChenDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Fang XuDepartment of Hematology, Mianyang Central Hospital, 12 Changjia Lane, Jingzhong Street, Mianyang, 621000, China.
Jirui TangDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Tao MaDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Min HuDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Dan LiuDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Jing GuoDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Xiaofeng ZhuDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Yan ChenDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
Ting YeLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Jianyu WangLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Xiaoming LiDepartment of Hematology, The Affiliated Hospital of Southwest Medical University, 25 Tai Ping Street, Luzhou, 646000, China.
H Rosie XingLaboratory of Translational Cancer Stem Cell Research, Institute of Life Sciences, Chongqing Medical University, 1 Yixueyuan Rd, Chongqing, 400016, China.
Affiliated Hospital of Southwest Medical University · CNChongqing Medical University · CNMianyang Central Hospital · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mantle cell lymphoma (MCL) is a B-cell malignancy with poor clinical outcome and undefined pathogenesis. Development of clinically relevant cellular models for MCL research is an urgent need. Our preliminary observations lead the development of two novel hypotheses that we tested in this study: 1. multicellular spheroid might be a unique growth mode of early-stage cells in MCL; 2. MCL might be a polyclonal tumor. We made the following original observations that have not been reported: First, we have provided a new experiment method for enriching MCL early-stage cells and characterized the spheroid mode of growth as a unique feature of early-stage MCL cells in cell line as well as in clinical samples. Second, we have established a clinically relevant cellular model of MCL, the

Indexed as

CD19JeKo-1-spheroidMantle cell lymphomaPathologySub-clone

Identifiers

PMID31832521
PMCPMC6889030
OpenAlexW2906626190

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.