Evidence map›Paper›PMID 31832448›Full record

ReviewEye and vision (London, England)2019

Optical coherence tomography angiography in diabetic retinopathy: a review of current applications.

Kai Yuan Tey, Kelvin Teo, Anna C S Tan, Kavya Devarajan, Bingyao Tan, Jacqueline Tan, Leopold Schmetterer, Marcus Ang

Open access · diamondAbstract readReview
In one paragraph

Review in Eye and vision (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
19.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 136 citations in OpenAlex.

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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Kai Yuan TeyHobart Clinical School, Level 3, 43 Collins Street, Hobart, TAS 7000 Australia.
Kelvin Teo2Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, 168751 Singapore.
Anna C S Tan2Singapore National Eye Centre, 11 Third Hospital Ave, Singapore, 168751 Singapore.
Kavya Devarajan3Singapore Eye Research Institute, 20 College Road Discovery Tower, Level 6 The Academia, Singapore, 169856 Singapore.
Bingyao Tan3Singapore Eye Research Institute, 20 College Road Discovery Tower, Level 6 The Academia, Singapore, 169856 Singapore.
Jacqueline Tan3Singapore Eye Research Institute, 20 College Road Discovery Tower, Level 6 The Academia, Singapore, 169856 Singapore.
Leopold Schmetterer3Singapore Eye Research Institute, 20 College Road Discovery Tower, Level 6 The Academia, Singapore, 169856 Singapore.
Marcus Ang4Singapore National Eye Centre, 11 Third Hospital Ave, Singapore 168751; Duke-NUS Medical School, 8 College Rd, Singapore, 169857 Singapore.ORCID 0000-0003-3022-0795
Singapore Eye Research Institute · SGSingapore National Eye Center · SGHobart Private Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetic retinopathy (DR) is a leading cause of vision loss in adults. Currently, the standard imaging technique to monitor and prognosticate DR and diabetic maculopathy is dye-based angiography. With the introduction of optical coherence tomography angiography (OCTA), it may serve as a potential rapid, non-invasive imaging modality as an adjunct. MAIN TEXT: Recent studies on the role of OCTA in DR include the use of vascular parameters e.g., vessel density, intercapillary spacing, vessel diameter index, length of vessels based on skeletonised OCTA, the total length of vessels, vascular architecture and area of the foveal avascular zone. These quantitative measures may be able to detect changes with the severity and progress of DR for clinical research. OCTA may also serve as a non-invasive imaging method to detect diabetic macula ischemia, which may help predict visual prognosis. However, there are many limitations of OCTA in DR, such as difficulty in segmentation between superficial and deep capillary plexus; and its use in diabetic macula edema where the presence of cystic spaces may affect image results. Future applications of OCTA in the anterior segment include detection of anterior segment ischemia and iris neovascularisation associated with proliferative DR and risk of neovascular glaucoma.

conclusionOCTA may potentially serve as a useful non-invasive imaging tool in the diagnosis and monitoring of diabetic retinopathy and maculopathy in the future. Future studies may demonstrate how quantitative OCTA measures may have a role in detecting early retinal changes in patients with diabetes.

Indexed as

Diabetic retinopathyFluorescein angiographyMonitoringOptical coherence tomography angiographyScreening

Identifiers

PMID31832448
PMCPMC6859616
OpenAlexW2989546055

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.