Evidence map›Paper›PMID 31832342›Full record

ArticleSchizophrenia research. Cognition2020

The characteristics of cognitive neuroscience tests in a schizophrenia cognition clinical trial: Psychometric properties and correlations with standard measures.

Michael S Kraus, James M Gold, Deanna M Barch, Trina M Walker, Charlotte A Chun, Robert W Buchanan, John G Csernansky, Donald C Goff, Michael F Green, L Fredrik Jarskog and 12 more

Open access · goldAbstract read
In one paragraph

Article in Schizophrenia research. Cognition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 1 country.

Michael S KrausDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States of America.
James M GoldMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States of America.
Deanna M BarchDepartment of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, United States of America.
Trina M WalkerDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States of America.
Charlotte A ChunTemple University, Philadelphia, PA, United States of America.
Robert W BuchananMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States of America.
John G CsernanskyDepartment of Psychiatry, Northwestern Feinberg School of Medicine, Chicago, IL, United States of America.
Donald C GoffDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, United States of America.
Michael F GreenUCLA Semel Institute for Neuroscience and Human Behavior, United States of America.
L Fredrik JarskogNorth Carolina Psychiatric Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, United States of America.
Daniel C JavittDepartment of Psychiatry, Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, New York, NY, United States of America.
David KimhyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Jeffrey A LiebermanDepartment of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons, Columbia University, United States of America.
Joseph P McEvoyDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States of America.
Raquelle I Mesholam-GatelyDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States of America.
Larry J SeidmanDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, United States of America.
M Patricia BallMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States of America.
Robert S KernUCLA Semel Institute for Neuroscience and Human Behavior, United States of America.
Robert P McMahonMaryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, United States of America.
James RobinsonDepartment of Psychiatry, Nathan Kline Institute for Psychiatric Research, New York University School of Medicine, New York, NY, United States of America.
Stephen R MarderUCLA Semel Institute for Neuroscience and Human Behavior, United States of America.
Richard S E KeefeDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States of America.
University of Maryland, Baltimore · USDuke Medical Center · USDuke University Hospital · USNew York University · USVA Desert Pacific Healthcare Network · USBeth Israel Deaconess Medical Center · USColumbia University · USHarvard University · USIcahn School of Medicine at Mount Sinai · USMassachusetts General Hospital · USMental Illness Research, Education and Clinical Centers · USNorthwestern University · USTemple University · USUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In comparison to batteries of standard neuropsychological tests, cognitive neuroscience tests may offer a more specific assessment of discrete neurobiological processes that may be aberrant in schizophrenia. However, more information regarding psychometric properties and correlations with standard neuropsychological tests and functional measures is warranted to establish their validity as treatment outcome measures. The N-back and AX-Continuous Performance Task (AX-CPT) are two promising cognitive neuroscience tests designed to measure specific components of working memory and contextual processing respectively. In the current study, we report the psychometric properties of multiple outcome measures from these two tests as well as their correlations with standard neuropsychological measures and functional capacity measures. The results suggest that while the AX-CPT and N-back display favorable psychometric properties, they do not exhibit greater sensitivity or specificity with functional measures than standard neurocognitive tests.

Identifiers

PMID31832342
PMCPMC6889798
OpenAlexW2987494826

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.