Evidence map›Paper›PMID 31832325›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019

Excretable Lanthanide Nanoparticle for Biomedical Imaging and Surgical Navigation in the Second Near-Infrared Window.

Daifeng Li, Shuqing He, Yifan Wu, Jianqiang Liu, Qiang Liu, Baisong Chang, Qing Zhang, Zhanhong Xiang, Ying Yuan, Chao Jian and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
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  6. Enzyme-responsive macrocyclic metal complexes for biomedical imaging.Bioengineering & translational medicine · 2023
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  12. Review
  13. Carbazole-Functionalized Dipicolinato LnJournal of luminescence · 2022
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Fluorescent Tracers forFrontiers in pharmacology · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daifeng LiDepartment of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China.
Shuqing HeMolecular Imaging Program at Stanford (MIPS) Bio-X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305-5344 USA.
Yifan WuDepartment of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China.
Jianqiang LiuDepartment of Orthopedics The Fourth Hospital of Jinan Jinan Shandong 250031 China.
Qiang LiuMolecular Imaging Program at Stanford (MIPS) Bio-X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305-5344 USA.
Baisong ChangMolecular Imaging Program at Stanford (MIPS) Bio-X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305-5344 USA.
Qing ZhangMolecular Imaging Program at Stanford (MIPS) Bio-X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305-5344 USA.
Zhanhong XiangMolecular Imaging Program at Stanford (MIPS) Bio-X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305-5344 USA.
Ying YuanDepartment of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China.
Chao JianDepartment of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China.
Aixi YuDepartment of Orthopedics Trauma and Microsurgery Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China.ORCID https://orcid.org/0000-0002-3751-0894
Zhen ChengMolecular Imaging Program at Stanford (MIPS) Bio-X Program and Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University Stanford CA 94305-5344 USA.ORCID https://orcid.org/0000-0001-8177-9463

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, various second near-infrared window (NIR-II, 1000-1700 nm) fluorophores have been synthesized for in vivo imaging with nonradiation, high resolution, and low autofluorescence. However, most of the NIR-II fluorophores, especially inorganic nanoprobes, are mainly retained in the reticuloendothelial system (RES) such as the liver and spleen, leading to long-term safety concerns. Herein, a type of lanthanide-based excretable NIR-II nanoparticle, RENPs@Lips, which can be quickly cleared out of body after intravenous administration with half-lives of 23.0 h for the liver and 14.9 h for the spleen, is reported. Interestingly, over 90% of RENPs@Lips can be excreted through a hepatobiliary system within 72 h postinjection. The moderate blood half-time (

Indexed as

excretable lanthanide nanoparticlesliposomessecond near‐infrared windowsurgical navigationvascular disorders imaging

Identifiers

PMID31832325
PMCPMC6891904

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.