ArticleNeuro-oncology practice2019
A prospective study of the natural history of incidental meningioma-Hold your horses!
Article in Neuro-oncology practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05254197 (The Risk of Growth in Patients With Non-malignant Brain Tumor), which is not on this map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Risk of Growth in Patients With Non-malignant Brain Tumor: SeOuL cOhort of Brain Tumor MONitoring (SOLOMON) Study
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- EANO guideline on the diagnosis and management of meningiomas.Neuro-oncology · 2021Guideline
- Natural History of Meningiomas: Review with Meta-analyses.Neurologia medico-chirurgica · 2020Pooled it
- Stereotactic radiosurgery for treating meningiomas eligible for complete resection.Radiation oncology (London, England) · 2021Trial
- Somatostatin receptor PET in meningioma: diagnosis, therapy, and surveillance.Nuclear medicine communications · 2026Review
- Spontaneous Regression of Meningiomas: Literature Review and Case Report.Asian journal of neurosurgery · 2026Article
- Novel predictors of tumor growth by exploratory quantitative analysis of radiomics features from MRI data for incidentally discovered meningioma.Journal of neuro-oncology · 2025Article
- Article
- Spontaneous Regression of Incidental Meningioma in the Posterior Cranial Fossa: A Case Report and Literature Review.Brain tumor research and treatment · 2025Article
- Article
- Prevalence and symptoms of incidental meningiomas: a population-based study.Acta neurochirurgica · 2025Article
- A multi-modal deep learning model for prediction of Ki-67 for meningiomas using pretreatment MR images.NPJ precision oncology · 2025Article
- Petroclival meningioma regression after combined oestrogen and nomegestrol acetate interruption.BMJ case reports · 2025Article
- Study of prediction model for high-grade meningioma using fractal geometry combined with radiological features.Journal of neuro-oncology · 2025Article
- Paradoxical evolution of spheno-orbital meningioma after cessation of progestin treatment.Surgical neurology international · 2025Article
- Exploring the role of volumetric and radiological features in meningioma behaviour and follow-up strategies.Brain & spine · 2025Article
- Radiographic predictors of peritumoral brain edema in intracranial meningiomas: a review of current controversies and illustrative cases.Chinese neurosurgical journal · 2024Review
- Spontaneous regression of a petroclival meningioma: illustrative case.Journal of neurosurgery. Case lessons · 2024Article
- Chronic hyperglycemia and intracranial meningiomas.BMC cancer · 2024Article
- Incidence, management, and outcome of incidental meningioma: what has happened in 10 years?Journal of neuro-oncology · 2023Article
- Growth dynamics of incidental meningiomas: A prospective long-term follow-up study.Neuro-oncology practice · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe number of incidental meningiomas has increased because of the increased availability of neuroimaging. Lack of prospective data on the natural history makes the optimal management unclear. We conducted a 5-year prospective study of incidental meningiomas to identify risk factors for tumor growth.
methodsSixty-four of 70 consecutive patients with incidental meningioma were included. Clinical and radiological status was obtained at 0, 0.5, 1, 1.5, 2, 3, 4, and 5 years. GammaPlan and mixed linear regression modeling were utilized for volumetric analysis with primary endpoint tumor growth.
resultsNone of the patients developed tumor-related symptoms during the study period, although 48 (75%) tumors increased (>15%), 13 (20.3%) remained unchanged, and 3 (4.7%) decreased (>15%) in volume. Mean time to growth was 2.2 years (range, 0.5-5.0 years).The growth pattern was quasi-exponential in 26%, linear in 17%, sigmoidal in 35%, parabolic in 17%, and continuous reduction in 5%. There was significant correlation among growth rate, larger baseline tumor volume (
conclusionThe majority of meningiomas will eventually grow. However, more than 60% display a self-limiting growth pattern. Our study provides level-2 evidence that asymptomatic tumors can be safely managed utilizing serial imaging until persistent radiological and/or symptomatic growth.
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