Evidence map›Paper›PMID 31832124›Full record

ArticleNano research2019

A theranostic agent for cancer therapy and imaging in the second near-infrared window.

Zhuoran Ma, Hao Wan, Weizhi Wang, Xiaodong Zhang, Takaaki Uno, Qianglai Yang, Jingying Yue, Hongpeng Gao, Yeteng Zhong, Ye Tian and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Molecular fluorophores for in vivo bioimaging in the second near-infrared window.European journal of nuclear medicine and molecular imaging · 2022
    Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Long-termNanoscale advances · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Dithieno[3,2-RSC advances · 2021
    Article
  16. Article
  17. Article
  18. Effects of Processing pH on Emission Intensity of Over-1000 nm Near-Infrared Fluorescence of Dye-Loaded Polymer Micelle with Polystyrene Core.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021
    Article
  19. Deep learning for in vivo near-infrared imaging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Zhuoran MaDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Hao WanDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Weizhi WangCAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China.
Xiaodong ZhangDepartment of Physics and Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Sciences, Tianjin University, Tianjin 300350, China.
Takaaki UnoJSR Corporation Advanced Materials Research Laboratories, 100 Kawajiri-Cho, Yokkaichi, Mie 5108552, Japan.
Qianglai YangDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen 518055, China.
Jingying YueDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Hongpeng GaoDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Yeteng ZhongDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Ye TianDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Qinchao SunDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Yongye LiangDepartment of Materials Science and Engineering, South University of Science and Technology of China, Shenzhen 518055, China.
Hongjie DaiDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Stanford University · USSouthern University of Science and Technology · CNNational Center for Nanoscience and Technology · CNTianjin University · CN

Funding

Human Infrared Vision at Molecular and Cellular ScaleDP1NS105737 · NINDS · STANFORD UNIVERSITY · PI DAI, HONGJIE · 2017 to 2022
$5.5M
NINDS NIH HHS DP1 NS105737
6 · The paper itself

Abstract

Theranostic nanoparticles are integrated systems useful for simultaneous diagnosis and imaging guided delivery of therapeutic drugs, with wide ranging potential applications in the clinic. Here we developed a theranostic nanoparticle (~ 24 nm size by dynamic light scattering) p-FE-PTX-FA based on polymeric micelle encapsulating an organic dye (FE) fluorescing in the 1,000-1,700 nm second near-infrared (NIR-II) window and an anti-cancer drug paclitaxel. Folic acid (FA) was conjugated to the nanoparticles to afford specific binding to molecular folate receptors on murine breast cancer 4T1 tumor cells.

Indexed as

cancer therapyfluorescence imagingsecond near-infrared windowtheranostic nanoparticles

Identifiers

PMID31832124
PMCPMC6907162
OpenAlexW2893134035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.