ArticleBiomicrofluidics2019
On-chip background dilution in droplets with high particle recovery using acoustophoresis.
Article in Biomicrofluidics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- From specialization to broad adoption: Key trends in droplet microfluidic innovations enhancing accessibility to non-experts.Biomicrofluidics · 2025Article
- Pico-washing: simultaneous liquid addition and removal for continuous-flow washing of microdroplets.Microsystems & nanoengineering · 2022Article
- A droplet acoustofluidic platform for time-controlled microbead-based reactions.Biomicrofluidics · 2021Article
- Acoustic focusing of beads and cells in hydrogel droplets.Scientific reports · 2021Article
- Manipulation of single cells inside nanoliter water droplets using acoustic forces.Biomicrofluidics · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Droplet microfluidics has shown great potential for on-chip biological and chemical assays. However, fluid exchange in droplet microfluidics with high particle recovery is still a major bottleneck. Here, using acoustophoresis, we present for the first time a label-free method to achieve continuous background dilution in droplets containing cells with high sample recovery. The system comprises droplet generation, acoustic focusing, droplet splitting, picoinjection, and serpentine mixing on the same chip. The capacities of the picoinjection and the droplet split to dilute the background fluorescent signal in the droplets have been characterized. The sample recovery at different droplet split ratios has also been characterized. The results show a maximum of 4.3-fold background dilution with 87.7% particle recovery. We also demonstrated that the system can be used to dilute background fluorescent signal in droplets containing either polystyrene particles or endothelial cells.
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Registered trials
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