Evidence map›Paper›PMID 31831886›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2020

The effect of leptin on blood pressure considering smoking status: a Mendelian randomization study.

Luqi Shen, José F Cordero, Jia-Sheng Wang, Ye Shen, Ruiyuan Zhang, Yanling Qi, Changwei Li

Abstract read
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In one paragraph

Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luqi ShenDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 120 B.S. Miller Hall, Health Sciences Campus, 101 Buck Road, Athens, GA, 30602, USA.
José F CorderoDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 120 B.S. Miller Hall, Health Sciences Campus, 101 Buck Road, Athens, GA, 30602, USA.
Jia-Sheng WangDepartment of Environmental Health Science, College of Public Health, University of Georgia, 150 East Green Street, Athens, GA, 30602, USA.
Ye ShenDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 120 B.S. Miller Hall, Health Sciences Campus, 101 Buck Road, Athens, GA, 30602, USA.
Ruiyuan ZhangDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 120 B.S. Miller Hall, Health Sciences Campus, 101 Buck Road, Athens, GA, 30602, USA.
Yanling QiDepartment of Health Care Administration, College of Health and Human Services, California State University, Long Beach, 1250 Bellflower Blvd, Long Beach, CA, 90840, USA.
Changwei LiDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, 120 B.S. Miller Hall, Health Sciences Campus, 101 Buck Road, Athens, GA, 30602, USA. changwei.li@uga.edu.
University of Georgia · USCalifornia State University, Long Beach · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies on leptin and blood pressure (BP) associations have yielded inconsistent findings. The current study aimed to evaluate the effect of genetically determined leptin on BP and to explore whether smoking status modified this effect. We conducted a Mendelian randomization analysis using the baseline data of 3860 participants in the Framingham Heart Study 3rd generation cohort. Pairwise associations among leptin genetic risk score (GRS), log-transformed leptin (log-leptin), and BP were assessed by multivariate linear regression models. Age and sex were adjusted in the base model, and education, smoking, drinking, and physical activity were adjusted in the full model. The interaction between leptin GRS and smoking was evaluated by adding an interaction term, GRS × smoking, in the fully adjusted model. In the age- and sex-adjusted analyses, log-leptin was positively associated with systolic BP (SBP) (P = 2.35 × 10

Indexed as

AdultBlood PressureBlood Pressure DeterminationFemaleGenetic LociGenotypeHumansLeptinMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideReceptors, LeptinRisk FactorsSmokingLeptinReceptors, LeptinBlood pressureGenetic risk scoreLeptinSmoking

Identifiers

PMID31831886
OpenAlexW2995552832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.