Evidence map›Paper›PMID 31831863›Full record

ReviewNature reviews. Neurology2020

Cannabinoids and the expanded endocannabinoid system in neurological disorders.

Luigia Cristino, Tiziana Bisogno, Vincenzo Di Marzo

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07362407 (Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments), which is not on this map. Cited by 485 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
485citing papers in PubMed, 4 pooled it
75.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07362407 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study (CANAREAL)

Typeobservational_patient_registrySponsorSanta Catarina Federal UniversityRan2026 to 2026Enrolled384ConditionsChronic Pain, Depression Disorders, Anxiety Disorders, Quality of LifeArmsParticipants are followed while using cannabis-based products (such as CBD or THC oils, extracts, or isolates) as prescribed by their own physicians for therapeutic purposes.
3 · Its place in the literature

Who cites it

485 citing papers in PubMed, 4 syntheses or guidelines pooled it, 947 citations in OpenAlex.

  1. Pooled it
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  9. Effects and safety of a CBD-richFrontiers in pharmacology · 2025
    Trial
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  12. Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  13. Cannabinoids in rehabilitation medicine: From controversy to clinical potential.Turkish journal of physical medicine and rehabilitation · 2026
    Article
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425 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 4 countries.

Luigia CristinoInstitute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy.ORCID http://orcid.org/0000-0002-0182-4699
Tiziana BisognoInstitute of Translational Pharmacology, Consiglio Nazionale delle Ricerche, Rome, Italy.ORCID http://orcid.org/0000-0002-5567-2272
Vincenzo Di MarzoInstitute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy. vincenzo.di-marzo.1@ulaval.ca.ORCID http://orcid.org/0000-0002-1490-3070
Istituto di Farmacologia Traslazionale · ITLung Institute · USNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anecdotal evidence that cannabis preparations have medical benefits together with the discovery of the psychotropic plant cannabinoid Δ

Indexed as

AnalgesicsAnimalsCannabidiolCannabinoidsDronabinolDrug CombinationsEndocannabinoidsHumansNervous System DiseasesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2AnalgesicsCannabidiolCannabinoidsDronabinolDrug CombinationsEndocannabinoidsnabiximolsReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2

Identifiers

PMID31831863
OpenAlexW2996080671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.