Evidence map›Paper›PMID 31831857›Full record

ArticleScientific reports2019

Bronchial epithelium repair by Esculentin-1a-derived antimicrobial peptides: involvement of metalloproteinase-9 and interleukin-8, and evaluation of peptides' immunogenicity.

Floriana Cappiello, Danilo Ranieri, Veronica Carnicelli, Bruno Casciaro, Han-Tang Chen, Loretta Ferrera, Y Peter Di, Maria Luisa Mangoni

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Wound repair and immune function in theFrontiers in cellular and infection microbiology · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Frog Skin-Derived Peptides AgainstAntibiotics (Basel, Switzerland) · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Floriana CappielloLaboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.
Danilo RanieriDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Veronica CarnicelliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Bruno CasciaroCenter for Life Nano Science, Istituto Italiano di Tecnologia, Rome, Italy.
Han-Tang ChenDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, USA.
Loretta FerreraU.O.C. Genetica Medica, Giannina Gaslini Institute, Genoa, Italy.
Y Peter DiDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, USA.
Maria Luisa MangoniLaboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy. marialuisa.mangoni@uniroma1.it.ORCID http://orcid.org/0000-0002-5991-5868
Istituto Pasteur · ITUniversity of Pittsburgh · USIstituto Giannina Gaslini · ITItalian Institute of Technology · ITSapienza University of Rome · ITUniversity of L'Aquila · IT

Funding

Novel antimicrobial agents to overcome antibiotic resistant Pseudomonas and MRSA respiratory infectionR01AI133351 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DI, YUANPU PETER · 2017 to 2021
$2.6M
SPLUNC1 in Severe AsthmaR01HL125128 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, HONG W, DI, YUANPU PETER · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL125128NIAID NIH HHS R01 AI133351
6 · The paper itself

Abstract

The airway epithelium is seriously damaged upon pulmonary Pseudomonas aeruginosa infection, especially in cystic fibrosis (CF) sufferers. Therefore, the discovery of novel anti-infective agents accelerating healing of infected injured tissues is crucial. The antipseudomonal peptides esculentin-1a(1-21)NH

Indexed as

Wound HealingAnimalsAntibodiesAntimicrobial Cationic PeptidesBronchiCell LineCell MovementCell ProliferationEpitheliumFemaleGlycosidesHumansInterleukin-8LipopolysaccharidesMaleMatrix Metalloproteinase 9AntibodiesAntimicrobial Cationic Peptidesesculentin steroidGlycosidesInterleukin-8LipopolysaccharidesMatrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPeptidesPregnenoloneRNA, Messenger

Identifiers

PMID31831857
PMCPMC6908641
OpenAlexW2995119490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.