ArticleScientific reports2019
Experience-dependent development of visual sensitivity in larval zebrafish.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mitochondrial ROS and HIF-1α signaling mediate synaptic plasticity in the critical period.PLoS biology · 2025Article
- Astrocyte regulation of critical period plasticity across neural circuits.Current opinion in neurobiology · 2025Review
- EFEMP1 contributes to light-dependent ocular growth in zebrafish.Biology open · 2024Article
- Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes.Scientific reports · 2024Article
- Functional neuronal circuits emerge in the absence of developmental activity.Nature communications · 2024Article
- Neural Endophenotype Assessment in Zebrafish Larvae Using Optomotor and ZebraBox Locomotion Assessment.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Ocular Necessities: A Neuroethological Perspective on Vertebrate Visual Development.Brain, behavior and evolution · 2024Review
- Spatiotemporal visual statistics of aquatic environments in the natural habitats of zebrafish.Scientific reports · 2023Article
- A behavioral and modeling study of control algorithms underlying the translational optomotor response in larval zebrafish with implications for neural circuit function.PLoS computational biology · 2023Article
- Optokinetic set-point adaptation functions as an internal dynamic calibration mechanism for oculomotor disequilibrium.iScience · 2022Article
- Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development.Annual review of neuroscience · 2022Review
- The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- DNA methylation and gene expression alterations in zebrafish embryos exposed to cadmium.Environmental science and pollution research international · 2021Article
- Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1.Investigative ophthalmology & visual science · 2021Article
- TheFrontiers in neural circuits · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The zebrafish (Danio rerio) is a popular vertebrate model for studying visual development, especially at the larval stage. For many vertebrates, post-natal visual experience is essential to fine-tune visual development, but it is unknown how experience shapes larval zebrafish vision. Zebrafish swim with a moving texture; in the wild, this innate optomotor response (OMR) stabilises larvae in moving water, but it can be exploited in the laboratory to assess zebrafish visual function. Here, we compared spatial-frequency tuning inferred from OMR between visually naïve and experienced larvae from 5 to 7 days post-fertilisation. We also examined development of synaptic connections between neurons by quantifying post-synaptic density 95 (PSD-95) in larval retinae. PSD-95 is closely associated with N-methyl-D-aspartate (NMDA) receptors, the neurotransmitter-receptor proteins underlying experience-dependent visual development. We found that rather than following an experience-independent genetic programme, developmental changes in visual spatial-frequency tuning at the larval stage required visual experience. Exposure to motion evoking OMR yielded no greater improvement than exposure to static form, suggesting that increased sensitivity as indexed by OMR was driven not by motor practice but by visual experience itself. PSD-95 density varied with visual sensitivity, suggesting that experience may have up-regulated clustering of PSD-95 for synaptic maturation in visual development.
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