ArticleScientific reports2019
A genomic predictor of lifespan in vertebrates.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Reading hominin life history in fossil bones and teeth: methods to test hypotheses regarding its evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Drivers of Thermal Habitat Use in Turtles Studied Under Semi-Natural Conditions.Ecology and evolution · 2026Article
- Epigenomic methylome landscape of promoters in vertebrate genomes.bioRxiv : the preprint server for biology · 2026Article
- Unintended evolutionary consequences of a minimum landing size regulations: Evidence and implications of fisheries-induced evolution.PloS one · 2026Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Multi-omic integration of single-cell data uncovers methylation profiles of super-enhancers in skeletal muscle stem cells.Epigenetics & chromatin · 2025Article
- The Influence of CG sites on dynamic DNA sequence mutagenesis in the genomic evolution of mammalian lifespan.Nucleic acids research · 2025Article
- Fish species lifespan prediction from promoter cytosine-phosphate-guanine density.Molecular ecology resources · 2025Article
- Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds.Advanced biology · 2025Article
- Identification of genes associated with longevity in dogs: 9 candidate genes described in Cavalier King Charles Spaniel.Veterinary and animal science · 2025Article
- Epigenetic clocks and programmatic aging.Ageing research reviews · 2024Review
- Universal prediction of vertebrate species age at maturity.Communications biology · 2024Article
- Epigenetic predictors of species maximum life span and other life-history traits in mammals.Science advances · 2024Article
- A genomic predictor for age at sexual maturity for mammalian species.Evolutionary applications · 2024Article
- The rate of epigenetic drift scales with maximum lifespan across mammals.Nature communications · 2023Article
- Survival rates and mortality risks of Plecturocebus cupreus at the California National Primate Research Center.American journal of primatology · 2023Article
- Universal DNA methylation age across mammalian tissues.Nature aging · 2023Article
- Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation.Science advances · 2023Article
- The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process.The journal of nutrition, health & aging · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological ageing and its mechanistic underpinnings are of immense biomedical and ecological significance. Ageing involves the decline of diverse biological functions and places a limit on a species' maximum lifespan. Ageing is associated with epigenetic changes involving DNA methylation. Furthermore, an analysis of mammals showed that the density of CpG sites in gene promoters, which are targets for DNA methylation, is correlated with lifespan. Using 252 whole genomes and databases of animal age and promotor sequences, we show a pattern across vertebrates. We also derive a predictive lifespan clock based on CpG density in a selected set of promoters. The lifespan clock accurately predicts maximum lifespan in vertebrates (R
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.