ArticleScientific reports2019
Early Life Maternal Separation and Maternal Behaviour Modulate Acoustic Characteristics of Rat Pup Ultrasonic Vocalizations.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Preserved social development but impaired executive function in aResearch square · 2026Article
- Sex-specific developmental phenotypes and their response to neonatalbioRxiv : the preprint server for biology · 2026Article
- Maternal separation increases anxiety-like phenotypes, fear responses, and altersNeurobiology of stress · 2026Article
- Elevated maternal testosterone induces sex-specific neurodevelopmental changes and ASD-related behavioral phenotypes in rat offspring.Pediatric research · 2026Article
- Maternal exposure to titanium dioxide nanoparticles disrupts ultrasonic vocalization development in mouse offspring.Particle and fibre toxicology · 2026Article
- 22 and 50 kHz rat ultrasonic vocalization playback reveals sex differences in behavior and cFos in brain regions associated with affective processing.Behavioural brain research · 2025Article
- Ultrasonic vocalisations in the Flinders Sensitive Line rat, a genetic animal model of depression.Acta neuropsychiatrica · 2025Article
- Stress-Induced Ultrasonic Vocalization in Laboratory Rats and Mice: A Scoping Review.Brain sciences · 2024Article
- Utilizing vocalizations to gain insight into the affective states of non-human mammals.Frontiers in veterinary science · 2024Review
- Comparing the effects of infant maternal and sibling separation on adolescent behavior in rats (Rattus norvegicus).PloS one · 2024Article
- Playback of rat 22-kHz ultrasonic vocalizations as a translational assay of negative affective states: An analysis of evoked behavior and brain activity.Neuroscience and biobehavioral reviews · 2023Review
- Mother-Young Bonding: Neurobiological Aspects and Maternal Biochemical Signaling in Altricial Domesticated Mammals.Animals : an open access journal from MDPI · 2023Review
- Assessment of the effects of sex, age, and rearing condition on ultrasonic vocalizations elicited by pups during the maternal potentiation paradigm in C57BL/6J mice.Developmental psychobiology · 2022Article
- Maternal stress and vulnerability to depression: coping and maternal care strategies and its consequences on adolescent offspring.Translational psychiatry · 2022Article
- Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity.Developmental psychobiology · 2022Article
- A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring.PLoS biology · 2022Article
- Moderate ethanol exposure during early ontogeny of the rat alters respiratory plasticity, ultrasonic distress vocalizations, increases brain catalase activity, and acetaldehyde-mediated ethanol intake.Frontiers in behavioral neuroscience · 2022Article
- Lactobacillus reuteri effects on maternal separation stress in newborn mice.Pediatric research · 2021Article
- Biological Functions of Rat Ultrasonic Vocalizations, Arousal Mechanisms, and Call Initiation.Brain sciences · 2021Review
- Trajectories of Mother-Infant Communication: An Experiential Measure of the Impacts of Early Life Adversity.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early separation of preterm infants from their mothers has adverse, long-term neurodevelopmental consequences. We investigated the effects of daily maternal separation (MS) of rat pups from postnatal days 2-10 (PND2-10) on neurobehavioural responses to brief isolation at PND12 compared with pups receiving controlled handling without MS. Ultrasonic vocalizations (USV) were measured at PND12 during two, 3-minute isolations occurring immediately before and after a 3-minute maternal reunion. There were no significant differences in acoustic characteristics between MS and control animals in the first isolation. However, in the second isolation, MS pups produced a greater proportion of high (~60 kHz) vs low (~40 kHz) frequency calls. During this isolation, control pups made longer and louder low frequency calls compared to the first isolation, whereas MS pups did the opposite. Maternal behaviour of control and MS mothers modulated pup acoustic characteristics in opposite directions; higher maternal care was associated with more low frequency calls in control pups but more high frequency calls in MS pups. We hypothesize that MS results in USV emission patterns reflective of a greater stress response to isolation. This translational model can be used to identify mechanisms and interventions that may be exploited to overcome the negative, long-term effects of MS.
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