Evidence map›Paper›PMID 31831739›Full record

ArticleNature communications2019

Hydroxyl-rich macromolecules enable the bio-inspired synthesis of single crystal nanocomposites.

Yi-Yeoun Kim, Robert Darkins, Alexander Broad, Alexander N Kulak, Mark A Holden, Ouassef Nahi, Steven P Armes, Chiu C Tang, Rebecca F Thompson, Frederic Marin and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Guanine Crystal Formation at Physiological pH.Crystal growth & design · 2025
    Article
  4. Review
  5. Polyamines Promote Aragonite Nucleation and Generate Biomimetic Structures.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  6. Calcite Kinks Grow via a Multistep Mechanism.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Positively Charged Additives Facilitate Incorporation in Inorganic Single Crystals.Chemistry of materials : a publication of the American Chemical Society · 2022
    Article
  11. Amyloid-like amelogenin nanoribbons template mineralization via a low-energy interface of ion binding sites.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yi-Yeoun KimSchool of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. y.y.kim@leeds.ac.uk.ORCID http://orcid.org/0000-0002-8503-4554
Robert DarkinsDepartment of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT, UK.
Alexander BroadDepartment of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT, UK.
Alexander N KulakSchool of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
Mark A HoldenSchool of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
Ouassef NahiSchool of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK.
Steven P ArmesDepartment of Chemistry, University of Sheffield, Brook Hill, Sheffield, S3 7HF, UK.
Chiu C TangDiamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK.
Rebecca F ThompsonThe Astbury Biostructure Laboratory, Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Frederic MarinUMR CNRS 6282 Biogeosciences, Université de Bourgogne-Franche-Comté, 6 Boulevard Gabriel, 21000, Dijon, France.
Dorothy M DuffyDepartment of Physics and Astronomy, University College London, Gower Street, London, WC1E 6BT, UK. d.duffy@ucl.ac.uk.ORCID http://orcid.org/0000-0002-8651-1463
Fiona C MeldrumSchool of Chemistry, University of Leeds, Woodhouse Lane, Leeds, LS2 9JT, UK. F.Meldrum@leeds.ac.uk.

Funding

Wellcome TrustWellcome Trust 108466/Z/15/Z
6 · The paper itself

Abstract

Acidic macromolecules are traditionally considered key to calcium carbonate biomineralisation and have long been first choice in the bio-inspired synthesis of crystalline materials. Here, we challenge this view and demonstrate that low-charge macromolecules can vastly outperform their acidic counterparts in the synthesis of nanocomposites. Using gold nanoparticles functionalised with low charge, hydroxyl-rich proteins and homopolymers as growth additives, we show that extremely high concentrations of nanoparticles can be incorporated within calcite single crystals, while maintaining the continuity of the lattice and the original rhombohedral morphologies of the crystals. The nanoparticles are perfectly dispersed within the host crystal and at high concentrations are so closely apposed that they exhibit plasmon coupling and induce an unexpected contraction of the crystal lattice. The versatility of this strategy is then demonstrated by extension to alternative host crystals. This simple and scalable occlusion approach opens the door to a novel class of single crystal nanocomposites.

Indexed as

BiomineralizationBiomimeticsCalcium CarbonateCrystallizationGlycoproteinsGoldMacromolecular SubstancesMetal NanoparticlesMineralsNanocompositesParticle SizeProteinsCalcium CarbonateGlycoproteinsGoldMacromolecular SubstancesMineralsProteins

Identifiers

PMID31831739
PMCPMC6908585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.