Evidence map›Paper›PMID 31831669›Full record

ArticleScience (New York, N.Y.)2019

Sensory coding mechanisms revealed by optical tagging of physiologically defined neuronal types.

Donghoon Lee, Maiko Kume, Timothy E Holy

Open access · greenAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
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  4. Cnpy1 is a candidate endoplasmic reticulum chaperone of vomeronasal type 2 GPCRs.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Donghoon LeeDepartment of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-0478-5821
Maiko KumeDepartment of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8014-444X
Timothy E HolyDepartment of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. holy@wustl.edu.ORCID 0000-0002-2429-1071
Washington University in St. Louis · US

Funding

IDENTITY AND NEURAL ENCODING OF SOCIAL ODORSR01DC010381 · NIDCD · WASHINGTON UNIVERSITY · PI Timothy Holy · 2009 to 2026
$5.1M
NEURAL MECHANISMS OF OLFACTORY PATTERN RECOGNITIONR01DC005964 · NIDCD · WASHINGTON UNIVERSITY · PI HOLY, TIMOTHY · 2004 to 2018
$4.7M
Fast volumetric imaging of large areas in deep brainUF1NS108176 · NINDS · WASHINGTON UNIVERSITY · PI HOLY, TIMOTHY · 2018 to 2018
$1.4M
NIDCD NIH HHS R01 DC005964NIDCD NIH HHS R01 DC010381NINDS NIH HHS UF1 NS108176
6 · The paper itself

Abstract

Neural circuit analysis relies on having molecular markers for specific cell types. However, for a cell type identified only by its circuit function, the process of identifying markers remains laborious. We developed physiological optical tagging sequencing (PhOTseq), a technique for tagging and expression profiling of cells on the basis of their functional properties. PhOTseq was capable of selecting rare cell types and enriching them by nearly 100-fold. We applied PhOTseq to the challenge of mapping receptor-ligand pairings among pheromone-sensing neurons in mice. Together with in vivo ectopic expression of vomeronasal chemoreceptors, PhOTseq identified the complete combinatorial receptor code for a specific set of ligands.

Indexed as

AnimalsCalciumChemoreceptor CellsMiceMice, TransgenicMolecular ImagingOptical ImagingPheromonesProtonsVomeronasal OrganCalciumPheromonesProtons

Identifiers

PMID31831669
PMCPMC7591936
OpenAlexW2996442841

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.