Evidence map›Paper›PMID 31831620›Full record

ArticleThe Journal of biological chemistry2020

Phosphatidylinositol 3,4-bisphosphate synthesis and turnover are spatially segregated in the endocytic pathway.

Haibin Wang, Dinah Loerke, Caroline Bruns, Rainer Müller, Philipp-Alexander Koch, Dmytro Puchkov, Carsten Schultz, Volker Haucke

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  14. Phosphoinositides as membrane organizers.Nature reviews. Molecular cell biology · 2022
    Review
  15. Article
  16. Structural basis of phosphatidylinositol 3-kinase C2α function.Nature structural & molecular biology · 2022
    Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Haibin WangLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Dinah LoerkeDepartment of Physics and Astronomy, University of Denver, Denver, Colorado 80208.
Caroline BrunsLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Rainer MüllerCell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0003-3464-494X
Philipp-Alexander KochLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany.
Dmytro PuchkovLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany.ORCID 0000-0001-8341-4847
Carsten SchultzCell Biology and Biophysics Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.
Volker HauckeLeibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125 Berlin, Germany haucke@fmp-berlin.de.ORCID 0000-0003-3119-6993
Leibniz-Forschungsinstitut für Molekulare Pharmakologie · DEEuropean Molecular Biology Laboratory · DEOregon Health & Science University · USUniversity of Denver · US

Funding

Chemical biology tools for studying growth factor receptor internalizationR01GM127631 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHULTZ, CARSTEN · 2018 to 2024
$2.4M
NIGMS NIH HHS R01 GM127631
6 · The paper itself

Abstract

Phosphoinositides play crucial roles in intracellular membrane dynamics and cell signaling, with phosphatidylinositol (PI) 3-phosphates being the predominant phosphoinositide lipids at endosomes and lysosomes, whereas PI 4-phosphates, such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Indexed as

EndocytosisSignal TransductionAnimalsCell Line, TumorChlorocebus aethiopsClathrinClathrin-Coated VesiclesCOS CellsEndosomesHumansMechanistic Target of Rapamycin Complex 1Phosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesProto-Oncogene Proteins c-aktrab5 GTP-Binding ProteinsClathrinearly endosome antigen 1Mechanistic Target of Rapamycin Complex 1phosphatidylinositol-3,4-bisphosphate 4-phosphatasephosphatidylinositol 3,4-diphosphatePhosphatidylinositol 3-Kinasesphosphatidylinositol 3-phosphatePhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesProto-Oncogene Proteins c-aktrab5 GTP-Binding ProteinsVesicular Transport ProteinsclathrinendocytosisendosomeimaginglysosomemTOR complex (mTORC)nutrient signalingphosphatidylinositol kinase (PI kinase)phosphatidylinositol phosphatasephosphoinositide

Identifiers

PMID31831620
PMCPMC6983852
OpenAlexW2995002624

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.