ArticleNeurology2020
Longitudinal associations between diurnal cortisol variation and later-life cognitive impairment.
Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Blunted diurnal cortisol slope as a risk marker for 9-year executive function decline: amplification by daily stress and worry severity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Chronic stress, cortisol dysregulation, and neurodegenerative vulnerability: mechanistic pathways linking HPA-axis dysfunction to Alzheimer's disease risk.Frontiers in aging neuroscience · 2026Review
- Clinical clusters during acute illness predict long-term mortality in older patients.BMC medicine · 2025Article
- Article
- Post-awakening cortisol and resilience: unravelling their impact on cognitive decline.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Cortisol and 10-Year Cognitive Decline in Older People From the General Population.European journal of neurology · 2025Article
- Sleep disturbances and psychomotor retardation in the prediction of cognitive impairments in patients with major depressive disorder.World journal of psychiatry · 2024Article
- Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland.Nature aging · 2024Article
- Circadian regulation of hippocampal function is disrupted with corticosteroid treatment.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Investigating longitudinal associations of hair cortisol and cortisone with cognitive functioning and dementia.Scientific reports · 2022Article
- Salivary cortisol in longitudinal associations between affective symptoms and midlife cognitive function: A British birth cohort study.Journal of psychiatric research · 2022Article
- Correlations Between Endocrine Hormones and Cognitive Function in Patients with Obesity: a Cross-sectional Study.Obesity surgery · 2022Article
- Exploring the relationship of sleep, cognition, and cortisol in sickle cell disease.Comprehensive psychoneuroendocrinology · 2022Article
- Alterations in Cortisol Profiles among Mothers of Children with ASD Related to Poor Child Sleep Quality.Healthcare (Basel, Switzerland) · 2022Article
- Socio-demographic and psychosocial predictors of salivary cortisol from older male participants in the Speedwell prospective cohort study.Psychoneuroendocrinology · 2022Article
- Hair Cortisol Concentration as a Biomarker of Sleep Quality and Related Disorders.Life (Basel, Switzerland) · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo determine whether hypothalamus-pituitary-adrenal axis (HPAA) dysfunction is prospectively associated with global cognitive impairment in later life.
methodsThis cross-cohort study integrates 2 large longitudinal datasets, Whitehall II and the National Survey for Health and Development (NSHD), on data collected in the Whitehall II study between 2002-2004, 2007-2009, and 2012-2013; and for NSHD between 2006-2010 and in 2015. Serial salivary cortisol samples were collected multiple times within a 24-hour period at mean ages 61.2 and 65.9 years in Whitehall II and at age 60-64 years from NSHD participants. Cortisol profile is defined using cortisol awakening response and am:pm ratio. Cognitive function was measured using the Mini-Mental State Examination in Whitehall II and Addenbrooke's Cognitive Examination, third version, in NSHD, harmonized into a 30-point score. Models were adjusted for age, sex, diagnoses of hypertension and diabetes, body mass index (BMI), educational attainment, and interval between HPAA and cognitive assessments.
resultsIn fully adjusted models, increased am:pm cortisol ratio was prospectively associated with better later-life cognitive function years later (0.02 fewer errors per SD increase in am:pm cortisol ratio,
conclusionsLoss of diurnal HPAA variation is evident in individuals subsequently experiencing more cognitive impairment. It may serve as an early preclinical marker of cognitive decline.
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