ArticleAmerican journal of preventive medicine2020
Perceived Discrimination and Trajectories of C-Reactive Protein: The Jackson Heart Study.
Article in American journal of preventive medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Racial/Ethnic Discrimination and Cardiometabolic Diseases: A Systematic Review.Journal of racial and ethnic health disparities · 2024Pooled it
- The association of urinary sodium with incident apparent treatment resistant hypertension among African Americans: findings from the Jackson Heart Study.Journal of human hypertension · 2026Article
- Queering Studies of Health and Bodily Experience: An Example From the Transgender Resilience and Health Study.American journal of biological anthropology · 2025Article
- A Community-Engaged Approach for Assessment of Cortisol Dynamic Range and Multilevel Chronic Stress in African Americans: FAITH! Heart Health+ Ancillary Study.Journal of participatory medicine · 2025Article
- Influence of Sex and Race or Ethnicity on Major Adverse Cardiovascular Outcomes Following Coronary Artery Bypass Surgery in a Large Integrated Health Care System.Journal of the American Heart Association · 2025Article
- The Effectiveness of a Race-Based Stress Reduction Intervention on Improving Stress-Related Symptoms and Inflammation in African American Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and Intervention for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Multilevel Mediators on the Associations of Neighborhood Social Environmental Factors and Severity of Metabolic Syndrome: The Jackson Heart Study.Journal of the American Heart Association · 2025Article
- Association Between Occupational Sitting With High Sensitivity C-Reactive Protein: The Jackson Heart Study.American journal of lifestyle medicine · 2025Article
- Discrimination, religious affiliation, and arterial stiffness in African American women and men.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Discrimination and Cardiovascular Health in Black Americans: Exploring Inflammation as a Mechanism and Perceived Control as a Protective Factor.Psychosomatic medicine · 2024Article
- Discrimination and Inflammation in Adolescents of Color.Biological psychiatry global open science · 2023Article
- Compositional analysis of movement behaviors' association on high-sensitivity c-reactive protein: the Jackson heart study.Annals of epidemiology · 2022Article
- Associations between perceived discrimination and immune cell composition in the Jackson Heart Study.Brain, behavior, and immunity · 2022Article
- Evidence for Revising the Adverse Childhood Experiences Screening Tool: a Scoping Review.Journal of child & adolescent trauma · 2022Article
- What's Race Got to Do With It? CRP Levels in Immune Mediated Skin Diseases: Considerations for Hidradenitis Suppurativa.Frontiers in immunology · 2022Article
- Psychosocial determinants of cardiovascular events among black Americans with chronic kidney disease or associated risk factors in the Jackson heart study.BMC nephrology · 2021Article
- Perceived racism, affectivity, and C-reactive protein in healthy African Americans: Do religiosity and racial identity provide complementary protection?Journal of behavioral medicine · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
introductionPerceiving discriminatory treatment may contribute to systemic inflammation, a risk factor of cardiovascular pathophysiology. This study evaluated the association of self-reported discrimination with changes in high-sensitivity C-reactive protein and the mediating role of adiposity.
methodsThe sample included 5,145 African-Americans, aged 21-92 years, in the Jackson Heart Study. Everyday, lifetime, and burden from perceived discrimination comprised primary predictors in 3 sets of multivariable linear regression models of baseline (2000-2004) discrimination and natural logarithm of high-sensitivity C-reactive protein. Multivariable linear mixed models assessed mean changes in natural logarithm of high-sensitivity C-reactive protein over the study period (2000-2013). Mediation was quantified by percentage changes in estimates adjusted for BMI, waist circumference, and waist-to-height ratio. Multiple imputation addressed missingness in baseline covariates and in high-sensitivity C-reactive protein taken at all 3 study examinations. Analyses were conducted in 2018.
resultsIn cross-sectional analyses, male participants in the middle and highest tertiles of lifetime discrimination had natural logarithm of high-sensitivity C-reactive protein levels that were 0.13 (95% CI= -0.24, -0.01) and 0.15 (95% CI= -0.27, -0.02) natural logarithm(mg/dL) lower than those in the lowest tertile. In longitudinal analyses, all participants reporting more frequent everyday discrimination had a 0.07 natural logarithm(mg/dL) greater increase in natural logarithm of high-sensitivity C-reactive protein per examination than those reporting none (95% CI=0.01, 0.12). A similar trend emerged for lifetime discrimination and changes in natural logarithm of high-sensitivity C-reactive protein (adjusted mean increase per visit: 0.04 natural logarithm[mg/dL], 95% CI=0.01, 0.08). Adiposity did not mediate the longitudinal associations.
conclusionsEveryday and lifetime discrimination were associated with significant high-sensitivity C-reactive protein increases over 13 years. The physiologic response to discrimination may lead to systemic inflammation.
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