Evidence map›Paper›PMID 31831262›Full record

SynthesisSchizophrenia research2020

Sleep and schizophrenia: From epiphenomenon to treatable causal target.

Felicity Waite, Bryony Sheaves, Louise Isham, Sarah Reeve, Daniel Freeman

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 9 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 9 syntheses or guidelines pooled it, 149 citations in OpenAlex.

  1. Pooled it
  2. The Australian and New Zealand journal of psychiatry · 2026
    Guideline
  3. Pooled it
  4. Pooled it
  5. EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence.European psychiatry : the journal of the Association of European Psychiatrists · 2024
    Pooled it
  6. Pooled it
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  9. Pooled it
  10. Trial
  11. Understanding excessive sleep in people with psychotic disorders.The British journal of clinical psychology · 2026
    Article
  12. Article
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  15. Review
  16. Article
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  18. Article
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  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Felicity WaiteDepartment of Psychiatry, University of Oxford, UK; Oxford Health NHS Foundation Trust, UK; Sleep and Circadian Neuroscience Institute, University of Oxford, UK. Electronic address: felicity.waite@psych.ox.ac.uk.
Bryony SheavesDepartment of Psychiatry, University of Oxford, UK; Oxford Health NHS Foundation Trust, UK; Sleep and Circadian Neuroscience Institute, University of Oxford, UK.
Louise IshamDepartment of Psychiatry, University of Oxford, UK; Oxford Health NHS Foundation Trust, UK.
Sarah ReeveUniversity College London, UK.
Daniel FreemanDepartment of Psychiatry, University of Oxford, UK; Oxford Health NHS Foundation Trust, UK; Sleep and Circadian Neuroscience Institute, University of Oxford, UK.
Oxford Health NHS Foundation Trust · GBUniversity College London · GB

Funding

Department of Health ICA-CDRF-2017-03-088Department of Health PB-PG-0211-10007Department of Health RP-2014-05-003Wellcome TrustWellcome Trust 098461/Z/12/Z
6 · The paper itself

Abstract

backgroundSleep disturbance is a common clinical issue for patients with psychosis. It has been identified as a putative causal factor in the onset and persistence of psychotic experiences (paranoia and hallucinations). Hence sleep disruption may be a potential treatment target to prevent the onset of psychosis and reduce persistent psychotic experiences. The aim of this review is to describe developments in understanding the nature, causal role, and treatment of sleep disruption in psychosis.

methodA systematic literature search was conducted to identify studies, published in the last five years, investigating subjective sleep disruption and psychotic experiences.

resultsFifty-eight papers were identified: 37 clinical and 21 non-clinical studies. The studies were correlational (n = 38; 20 clinical, 18 non-clinical), treatment (n = 7; 1 non-clinical), qualitative accounts (n = 6 clinical), prevalence estimates (n = 5 clinical), and experimental tests (n = 2 non-clinical). Insomnia (50%) and nightmare disorder (48%) are the most prevalent sleep problems found in patients. Sleep disruption predicts the onset and persistence of psychotic experiences such as paranoia and hallucinations, with negative affect identified as a partial mediator of this relationship. Patients recognise the detrimental effects of disrupted sleep and are keen for treatment. All psychological intervention studies reported large effect size improvements in sleep and there may be modest resultant improvements in psychotic experiences.

conclusionsSleep disruption is a treatable clinical problem in patients with psychosis. It is important to treat in its own right but may also lessen psychotic experiences. Research is required on how this knowledge can be implemented in clinical services.

Indexed as

Psychotic DisordersSchizophreniaDelusionsHallucinationsHumansParanoid DisordersSleepDelusionsHallucinationsInsomniaPsychosisSchizophreniaTreatment

Identifiers

PMID31831262
PMCPMC7327507
OpenAlexW2996640285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.