Evidence map›Paper›PMID 31831066›Full record

ArticleActa neuropathologica communications2019

Tau pathology in the medial temporal lobe of athletes with chronic traumatic encephalopathy: a chronic effects of neurotrauma consortium study.

Christy M Kelley, Sylvia E Perez, Elliott J Mufson

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Thioflavin S Staining and Amyloid Formation Are Unique to Mixed Tauopathies.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christy M KelleyDepartment of Neurobiology and Neurology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ, 85013, USA.
Sylvia E PerezDepartment of Neurobiology and Neurology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ, 85013, USA.
Elliott J MufsonDepartment of Neurobiology and Neurology, Barrow Neurological Institute, 350 West Thomas Rd, Phoenix, AZ, 85013, USA. Elliott.Mufson@DignityHealth.org.
Barrow Neurological Institute · US

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo ImagingU01NS086659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MCKEE, ANN C. · 2014 to 2017
$6.1M
NIA NIH HHS P30 AG013846NINDS NIH HHS U01 NS086659U.S. Department of Defense W81XWH-13-2-0095
6 · The paper itself

Abstract

Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative condition associated with repetitive traumatic brain injury (rTBI) seen in contact-sport athletes and military personnel. The medial temporal lobe (MTL; i.e., hippocampus, subiculum, and entorhinal and perirhinal cortices) memory circuit displays tau lesions during the pathological progression of CTE. We examined MTL tissue obtained from 40 male Caucasian and African American athletes who received a postmortem CTE neuropathological diagnosis defined as stage II, III, or IV. Sections were immunolabeled using an early (AT8) or a late (TauC3) marker for pathological tau and for amyloid beta (Aβ) species (6E10, Aβ

Indexed as

AthletesAdultAgedAged, 80 and overAthletic InjuriesBrain Injuries, TraumaticChronic Traumatic EncephalopathyHumansMaleMiddle AgedRetrospective Studiestau ProteinsTemporal LobeMAPT protein, humantau ProteinsAthletesChronic traumatic encephalopathyHippocampusMedial temporal lobeRepetitive traumatic brain injuryTau

Identifiers

PMID31831066
PMCPMC6909582
OpenAlexW2994690787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.