ArticleVeterinary research2019
Lsr operon is associated with AI-2 transfer and pathogenicity in avian pathogenic Escherichia coli.
Article in Veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Repurposing loratadine to reverse colistin resistance inEmerging microbes & infections · 2026Article
- Quorum-sensing regulator LsrR modulates resistance to oxidative stress by interfering with sulfate assimilation in avian pathogenicJournal of bacteriology · 2026Article
- An IgM monoclonal antibody targeting diguanylate cyclase DgcE potentiates gentamicin activity against avian pathogenic Escherichia coli through modulation of c-di-GMP signaling.BMC veterinary research · 2026Article
- Clove Oil Enhances Fosfomycin Efficacy AgainstBiomolecules · 2026Article
- Isoferulic acid suppressesFrontiers in microbiology · 2026Article
- Quercetin Can Alleviate ETECK88-Induced Oxidative Stress in Weaned Piglets by Inhibiting Quorum-Sensing Signal Molecule Autoinducer-2 Production in the Cecum.Antioxidants (Basel, Switzerland) · 2025Article
- Dihydromyricetin alleviates ETEC K88-induced intestinal inflammatory injury by inhibiting quorum sensing-related virulence factors.BMC microbiology · 2025Article
- Transcriptional response study of auto inducer-2 regulatory system in Escherichia coli harboring blaBMC microbiology · 2025Article
- Less is more: the lack of autoinducer-2-dependent quorum sensing promotes competitive fitness ofFrontiers in cellular and infection microbiology · 2025Article
- Study on the antibacterial effect of the new anti-biofilm inhibitor ICAC onFrontiers in cellular and infection microbiology · 2025Article
- Phenotypic and transcriptomic analysis reveals the antibiofilm mechanism ofCurrent research in food science · 2025Article
- Effect of Solid-State Fermentation Products ofVeterinary sciences · 2024Article
- Klebsiella pneumoniae AI-2 transporters mediate interspecies interactions and composition in a three-species biofilm community.NPJ biofilms and microbiomes · 2024Article
- Article
- Fingolimod Inhibits Exopolysaccharide Production and Regulates Relevant Genes to Eliminate the Biofilm ofInternational journal of molecular sciences · 2024Article
- Physiological and Transcriptomic Analyses ofMicroorganisms · 2023Article
- Anti-Quorum Sensing Activity of Probiotics: The Mechanism and Role in Food and Gut Health.Microorganisms · 2023Review
- Novel Antibiofilm Inhibitor Ginkgetin as an Antibacterial Synergist againstInternational journal of molecular sciences · 2022Article
- To kill or to be killed: pangenome analysis of Escherichia coli strains reveals a tailocin specific for pandemic ST131.BMC biology · 2022Article
- Identification of novel biofilm genes in avian pathogenic Escherichia coli by Tn5 transposon mutant library.World journal of microbiology & biotechnology · 2022Review
Corrections and comments
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
The function of Autoinducer-2 (AI-2) which acts as the signal molecule of LuxS-mediated quorum sensing, is regulated through the lsr operon (which includes eight genes: lsrK, lsrR, lsrA, lsrC, lsrD, lsrB, lsrF, and lsrG). However, the functions of the lsr operon remain unclear in avian pathogenic Escherichia coli (APEC), which causes severe respiratory and systemic diseases in poultry. In this study, the presence of the lsr operon in 60 APEC clinical strains (serotypes O1, O2, and O78) was investigated and found to be correlated with serotype and has the highest detection rate in O78. The AI-2 binding capacity of recombinant protein LsrB of APEC (APEC-LsrB) was verified and was found to bind to AI-2 in vitro. In addition, the lsr operon was mutated in an APEC strain (APEC94Δlsr(Cm)) and the mutant was found to be defective in motility and AI-2 uptake. Furthermore, deletion of the lsr operon attenuated the virulence of APEC, with the LD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.