ArticleAnnals of clinical microbiology and antimicrobials2019
Molecular detection and antibiotic resistance pattern of extended-spectrum beta-lactamase producing Escherichia coli in a Tertiary Hospital in Enugu, Nigeria.
Article in Annals of clinical microbiology and antimicrobials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 45 citations in OpenAlex.
- ESBL-ProducingVeterinary sciences · 2025Article
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- Multidrug-Resistant Bacteria in Immunocompromised Patients.Pharmaceuticals (Basel, Switzerland) · 2024Review
- High prevalence of carbapenem-resistantHeliyon · 2024Article
- Genotypic and phenotypic characterization of determinants that mediate antimicrobial resistance inJournal of infection prevention · 2024Article
- The Prevalence of Multidrug-ResistantDiagnostics (Basel, Switzerland) · 2023Article
- High prevalence of extensively drug resistant and extended spectrum beta lactamases (ESBLs) producing uropathogenic Escherichia coli isolated from Faisalabad, Pakistan.World journal of microbiology & biotechnology · 2023Article
- Distribution of ß-Lactamase Genes Among Multidrug-Resistant and Extended-Spectrum ß-Lactamase-Producing DiarrheagenicInfection and drug resistance · 2023Article
- Antibiogram and molecular characterization of extended-spectrum β-lactamase-producing pathogens implicated in chronic suppurative otitis media.The Pan African medical journal · 2023Article
- Clinical Feature, Therapy, Antimicrobial Resistance Gene Distribution, and Outcome of Nosocomial Meningitis Induced by Multidrug-Resistant Enterobacteriaceae-A Longitudinal Cohort Study From Two Neurosurgical Centers in Northern China.Frontiers in cellular and infection microbiology · 2022Article
- Beta-lactamase resistance genes inAfrican journal of laboratory medicine · 2022Review
- Antibiotic-resistant pathogenic bacterial isolates from patients attending the outpatient department of university of Cape Coast hospital, Ghana: A retrospective study between 2013-2015.PLOS global public health · 2022Article
- Monitoring and Early Warning Analysis of the Epidemic Situation ofJournal of healthcare engineering · 2022Article
- Molecular characterization of extended spectrum cephalosporin resistantFrontiers in microbiology · 2022Article
- Frequency of Beta-Lactamase Antibiotic Resistance Genes inEthiopian journal of health sciences · 2021Article
- Antibiotic resistance and ESBL production inBulletin of the National Research Centre · 2021Article
- Whole-Genome Sequencing-Based Antimicrobial Resistance Characterization and Phylogenomic Investigation of 19 Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-PositiveFrontiers in microbiology · 2021Article
- Antimicrobial resistance in hospitalized surgical patients: a silently emerging public health concern in Benin.Annals of clinical microbiology and antimicrobials · 2020Article
- Genetic relatedness in extended-spectrum beta-lactamase-producingInternational journal of health sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of antibiotic agents in the treatment of infectious diseases has greatly contributed to the decrease in morbidity and mortality, but these great advances in treatment are being undermined by the rapidly increasing antimicrobial resistant organisms. Extended-spectrum beta-lactamases are enzymes hydrolyzing the beta lactam antibiotics, including third generation cephalosporins and monobactams but not cephamycins and carbapenems. They pose a serious global health threat and have become a challenge for health care providers. The aim of this research was to assess the prevalence of extended-spectrum beta-lactamase producing Escherichia coli in University of Nigeria Teaching Hospital Ituku-Ozalla Enugu and to detect the risk factors for acquisition of the resistant organism. To proffer advice on antibiotic stewardship in clinical practice and public health interventions, to curb the spread of the resistant organisms in the hospital.
resultsOut of the 200 E. coli isolates, 70 (35.00%) were confirmed positive for extended-spectrum beta-lactamase production. Fifty-three (75.7%) were from hospital acquired infections. All the isolates were resistant to ampicillin, tetracycline and chloramphenicol while 68 (97.14%) of the 70 isolates were susceptible to imipenem. Bla
conclusionThere is a high rate of infections caused by extended-spectrum beta-lactamase producing E. coli. Recent surgery, previous antibiotic and intensive care unit admission were associated risk factors.
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