ArticleThe Korean journal of internal medicine2020
Effect of biologics in the level of cytokines in the synovial fluid of patients with ankylosing spondylitis.
Article in The Korean journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Nonclinical safety assessment of SBT777101, a CAR-engineered regulatory T cell therapy for autoimmune diseases.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Hyaluronic Acid in Synovial Fluid Prevents Neutrophil Activation in Spondyloarthritis.International journal of molecular sciences · 2023Article
- The Diagnostic and Prognostic Value of Synovial Fluid Analysis in Joint Diseases.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity.International journal of molecular sciences · 2022Article
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- IL-17F promotes osteoblastic osteogenesis via the MAPK/ERK1/2 signaling pathway.Experimental and therapeutic medicine · 2021Article
- The role of ixekizumab in non-radiographic axial spondyloarthritis.Therapeutic advances in musculoskeletal disease · 2021Article
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6 authors at 3 institutions in 1 country.
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Abstract
BACKGROUND/
aimsBiologics are very effective drugs for patients with ankylosing spondylitis (AS). However, there are patients who are not responding to biologics. This study aimed to evaluate the level of tumor necrosis factor α (TNF-α), interleukin (IL)-23, and IL-17 from synovial fluid in patients with AS and rheumatoid arthritis (RA) and differences of the level of those cytokines according to drugs.
methodsSynovial fluid was obtained from 34 patients (42 samples) with AS and 45 patients (47 samples) with RA with active arthritis of the knee, and the cytokine levels were measured. The differences in the levels between patients treated with and without biologics (biologics and non-biologics groups, respectively) were analyzed in AS and RA. The correlations between cytokines were examined in the non-biologics and biologics groups.
resultsThe TNF-α level in AS was significantly lower than that in RA (p = 0.016). The IL-17 and IL-23 levels were not different between AS and RA (p = 0.409 and p = 0.562, respectively). In AS and RA, TNF-α, IL-17, and IL-23 showed good correlation among each other in the non-biologics group. However, there was no significant correlation in biologics group. In some patients in the AS group, the IL-17 or IL-23 level was markedly elevated in the biologics group.
conclusionTreatment with biologics affects the cytokine profile in inflammatory synovial fluid in patients with both AS and RA. Furthermore, IL-23 and IL-17 cytokine might be an important factor in some patients who are unresponsive to biologics in AS.
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