ReviewPediatric research2020
Postnatal skeletal growth is driven by the epiphyseal stem cell niche: potential implications to pediatrics.
Review in Pediatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Dynamin inhibitor dynasore modulates longitudinal bone growth in a hormetic manner.BMC biology · 2026Article
- Growth hormone regulates the stem cell population in the growth plate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The role of the PTHrP/Ihh feedback loop in the unusual growth plate location in mammalian metatarsals and pisiforms.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Egg Yolk Granule Nanoparticles Promote Longitudinal Bone Growth in HFD-Obese Mice.Foods (Basel, Switzerland) · 2025Article
- Stem Cell Niche Concept: Search for Current Expert Consensus.International journal of molecular sciences · 2025Review
- Exploring the impact of mechanical stimuli on growth plate morphology and trabecular adaptation: A finite element approach.Journal of orthopaedics · 2025Article
- Timing of resting zone parathyroid hormone-related protein expression affects maintenance of the growth plate during secondary ossification: a computational study.Biomechanics and modeling in mechanobiology · 2025Article
- Growth plate closure and therapeutic interventions.Clinical and experimental pediatrics · 2024Article
- A protocol to differentiate the chondrogenic ATDC5 cell-line for the collection of chondrocyte-derived extracellular vesicles.Journal of extracellular biology · 2024Article
- MRI and single-cell RNA sequence results reveal the influence of anterior talofibular ligament injury on osteochondral lesions of the talus.Journal of orthopaedic surgery and research · 2024Article
- Bone Age Determination of Epiphyseal Fusion at Knee Joint and Its Correlation with Chronological Age.Medicina (Kaunas, Lithuania) · 2024Article
- Rheb1 is required for limb growth through regulating chondrogenesis in growth plate.Cell and tissue research · 2024Article
- Stimulation of skeletal stem cells in the growth plate promotes linear bone growth.JCI insight · 2024Article
- Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency.JCI insight · 2024Article
- The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting.Current osteoporosis reports · 2023Review
- Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation.Bone reports · 2023Article
- Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples.Nature communications · 2023Article
- Article
- Ciliary IFT88 Protects Coordinated Adolescent Growth Plate Ossification From Disruptive Physiological Mechanical Forces.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Suppressor of fused-restrained Hedgehog signaling in chondrocytes is critical for epiphyseal growth plate maintenance and limb elongation in juvenile mice.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children's longitudinal growth is facilitated by the activity of the growth plates, cartilage discs located near the ends of the long-bones. In order to elongate these bones, growth plates must continuously generate chondrocytes. Two recent studies have demonstrated that there are stem cells and a stem cell niche in the growth plate, which govern the generation of chondrocytes during the postnatal growth period. The niche, which allows stem cells to renew, appears at the same time as the secondary ossification center (SOC) matures into a bone epiphysis. Thus, the mechanism of chondrocyte generation differs substantially between neonatal and postnatal age, i.e., before and after the formation of the mineralized epiphyses. Hence, at the neonatal age bone growth is based on a consumption of chondro-progenitors whereas postnatally it is based on the activity of the stem cell niche. Here we discuss potential implications of these observations in relation to longitudinal growth, including the effects of estrogens, nutrition and growth hormone.
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