ArticleNature2020
A developmental landscape of 3D-cultured human pre-gastrulation embryos.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 262 papers.
0numbers the graph read from it
0cells of the map it votes in
262citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
262 citing papers in PubMed.
- Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface.Stem cell reports · 2026Article
- Gene regulation at the early human maternal-fetal interface.Nature reviews. Genetics · 2026Review
- Evaluation of the clinical utility of poor-quality embryos using an extended in vitro embryo culture system.The Journal of reproduction and development · 2026Article
- Engineering the human endometrium at the intersection of development and reproduction.Nature biomedical engineering · 2026Review
- Placental TRPV2 supports trophoblast function and normal fetal development.Nature communications · 2026Article
- Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions.Science China. Life sciences · 2026Review
- A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species.Cell research · 2026Article
- Article
- Establishment of Human Formative Pluripotent Stem Cell-Like Cells Exhibiting Amniotic Differentiation Potentials.Cell proliferation · 2026Article
- A single small molecule-based human embryo model reveals V-ATPase requirement in mammalian blastocyst cavitation.Cell research · 2026Article
- A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos.Nature cell biology · 2026Article
- Beyond integration: towards benchmarks for developmental potential in human stem cell-derived embryo models.Human reproduction update · 2026Review
- Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator.Nucleic acids research · 2026Article
- The vertebrate yolk sac: evolutionary origins and current advances in in vitro models.Development (Cambridge, England) · 2026Review
- Synthetic embryos: current progress, application and challenges.Reproductive biology and endocrinology : RB&E · 2026Review
- Stem cell-based embryo models as a tool for reproductive biology.Molecular human reproduction · 2026Review
- Serum coating enables feeder-free culture of naive human pluripotent stem cells preserving developmental potential.The EMBO journal · 2026Article
- Endogenous VEGF signaling acts as a guardian of human primed pluripotency.Nature communications · 2026Article
- Progress in stem cell-based embryo models and their applications in developmental biology and biomedicine.Nature reviews. Molecular cell biology · 2026Review
- Amniogenesis in embryos and stem cell models.Nature cell biology · 2026Review
202 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors.
Lifeng Xiang *Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yu Yin *Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yun Zheng *Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yanping Ma *Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, China.
Yonggang Li *Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, China.
Zhigang ZhaoYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Junqiang GuoYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Zongyong AiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yuyu NiuYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Kui DuanYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Jingjing HeYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Shuchao RenYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Dan WuYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.
Yun BaiDepartment of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, China.
Zhouchun ShangBGI-Shenzhen, Shenzhen, China.
Xi DaiBGI-Shenzhen, Shenzhen, China.
Weizhi JiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China. wji@lpbr.cn.
Tianqing LiYunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China. litq@lpbr.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our understanding of how human embryos develop before gastrulation, including spatial self-organization and cell type ontogeny, remains limited by available two-dimensional technological platforms
Indexed as
Embryonic DevelopmentAmnionBlastocystCell Culture TechniquesCell DifferentiationCell LineageCell PolarityCollagenDrug CombinationsEmbryo, MammalianEpitheliumGastrulationGerm LayersHumansLamininPrimitive StreakCollagenDrug CombinationsLamininmatrigelProteoglycansTranscription Factors
Identifiers
PMID
31830756What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.