Evidence map›Paper›PMID 31830586›Full record

ReviewAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2020

EoE disease monitoring: Where we are and where we are going.

Bridget Godwin, Benjamin Wilkins, Amanda B Muir

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03822325 active not recruitingnot on this map

Inflammatory Mediators as Potential Non-Invasive Biomarkers and Understanding the Mechanism of Remodeling in Tissue Biopsies in Subjects With Eosinophilic Esophagitis: A Pilot Study

Typeobservational_patient_registrySponsorAnn & Robert H Lurie Children's Hospital of ChicagoRan2011 to 2027Enrolled88ConditionsEosinophilic Esophagitis
NCT05199532 recruitingnot on this map

Eosinophilic Gastrointestinal Disorders Registry

Typeobservational_patient_registrySponsorAnn & Robert H Lurie Children's Hospital of ChicagoRan2020 to 2035Enrolled500ConditionsEosinophilic Esophagitis, Eosinophilic Gastroenteritis, Eosinophilic Colitis, Eosinophilic Gastrointestinal Disease
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. EoE behaves as a unique Th2 disease: a narrative review.Translational gastroenterology and hepatology · 2023
    Review
  11. Eosinophilic esophagitis: Immune mechanisms and therapeutic targets.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022
    Review
  12. Advancing Eosinophilic Esophagitis Diagnosis and Phenotype Assessment with Deep Learning Computer Vision.Biomedical engineering systems and technologies, international joint conference, BIOSTEC ... revised selected papers. BIOSTEC (Conference) · 2021
    Article
  13. How to approach adult patients with asymptomatic esophageal eosinophilia.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021
    Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bridget GodwinDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Benjamin WilkinsDepartment of Pathology and Laboratory Medicine, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Amanda B MuirDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, Perlman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: muira@email.chop.edu.

Funding

TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Marc E. Rothenberg · 2014 to 2026
$18.5M
Lysyl oxidase mediated fibrosis in eosinophilic esophagitisK08DK106444 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI MUIR, AMANDA BROOKE · 2015 to 2019
$778k
Distensibility and Remodeling as markers of Therapeutic Response in Eosinophilic EsophagitisR21TR003039 · NCATS · CHILDREN'S HOSP OF PHILADELPHIA · PI MENARD-KATCHER, CALIES D, MUIR, AMANDA BROOKE · 2019 to 2020
$422k
The Role of Lysyl Oxidase in Epithelial Differentiation in Eosinophilic EsophagitisR03DK118310 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI MUIR, AMANDA BROOKE · 2019 to 2020
$264k
NCATS NIH HHS R21 TR003039NIAID NIH HHS U54 AI117804NIDDK NIH HHS K08 DK106444NIDDK NIH HHS R03 DK118310
6 · The paper itself

Abstract

objectiveTo review literature on various methods of monitoring and characterizing eosinophilic esophagitis (EoE) with respect to their validity as well as risk to the patient. DATA SOURCES: A literature search was performed using PubMed with keyword combinations of EoE and monitoring as well as various techniques used for monitoring, including but not limited to, symptoms, endoscopy, histology, fluoroscopy, FLIP, noninvasive monitoring, and biomarkers. STUDY SELECTIONS: Case-control studies, observational studies, peer-reviewed reviews and guidelines, and systematic reviews were selected, reviewed, and summarized here.

resultsA wealth of research regarding monitoring of EoE is currently being undertaken and published. Our review highlights those that have been validated and are currently being used, as well as some that show promise for future monitoring and disease characterization.

conclusionEosinophilic esophagitis is a chronic condition that at this time requires upper endoscopy as the gold standard of diagnosis and monitoring. There is a great need in the field for less invasive monitoring tools and better ways to characterize disease to allow for personalization of therapies.

Indexed as

BiomarkersDisease ManagementEosinophilic EsophagitisEsophagoscopyHumansImage Processing, Computer-AssistedPhenotypePrecision MedicinePublic Health SurveillanceSeverity of Illness IndexBiomarkers

Identifiers

PMID31830586
PMCPMC7059875

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.