Evidence map›Paper›PMID 31830059›Full record

ArticlePloS one2019

The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder.

Lindsay C Hanford, Kristen Eckstrand, Anna Manelis, Danella M Hafeman, John Merranko, Cecile D Ladouceur, Simona Graur, Alicia McCaffrey, Kelly Monk, Lisa K Bonar and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Lindsay C HanfordWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.ORCID 0000-0002-5788-9651
Kristen EckstrandWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Anna ManelisWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Danella M HafemanWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
John MerrankoWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Cecile D LadouceurWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Simona GraurWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Alicia McCaffreyWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Kelly MonkWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Lisa K BonarWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Mary Beth HickeyWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Tina R GoldsteinWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Benjamin I GoldsteinPsychiatry, Sunnybrook Health Sciences Centre, Toronto, Canada.
David AxelsonNationwide Children's Hospital and The Ohio State College of Medicine, Columbus, Ohio, United States of America.
Genna BebkoWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Michele A BertocciWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Mary Kay GillWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Boris BirmaherWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Mary L PhillipsWestern Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
University of Pittsburgh Medical Center · USNationwide Children's Hospital · USSunnybrook Health Science Centre · CA

Funding

Children of Bipolar Parents: A High Risk Follow Up Study (also known as Bipolar Offspring Study - BIOS)R01MH060952 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2001 to 2020
$20.4M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073953 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2005 to 2016
$8.7M
NIMH NIH HHS R01 MH060952NIMH NIH HHS R01 MH073953
6 · The paper itself

Abstract

A recently developed risk calculator for bipolar disorder (BD) accounts for clinical and parental psychopathology. Yet, it is understood that both familial predisposition and early life adversity contribute to the development of BD. How the interplay between these two factors influence emotion and reward processing networks in youth at risk for BD remains unclear. In this exploratory analysis, offspring of BD parents performed emotion and reward processing tasks while undergoing a fMRI scan. Risk calculator score was used to assess risk for developing BD in the next 5 years. Environmental risk was tabulated using the Stressful Life Events Schedule (SLES). Emotion and reward processing networks were investigated for genetic and/or environment interactions. Interaction effects were found between risk calculator scores, negative SLES score and activity in right amygdala and bilateral fusiform gyri during the emotion processing task, as well as activity in the fronto-, striatal, and parietal regions during the reward processing task. Our findings are preliminary; however, they support the unique and interactive contributions of both familial and environmental risk factors on emotion and reward processing within OBP. They also identify potential neural targets to guide development of interventions for youth at greatest risk for psychiatric disorders.

Indexed as

EmotionsGenetic Predisposition to DiseaseNeural PathwaysRewardAdolescentAdverse Childhood ExperiencesBipolar DisorderChildFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleStress, Psychological

Identifiers

PMID31830059
PMCPMC6907842
OpenAlexW2997778417

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.