Evidence map›Paper›PMID 31829240›Full record

ArticleBMC complementary and alternative medicine2019

The effectiveness of traditional Japanese medicine Goshajinkigan in irradiation-induced aspermatogenesis in mice.

Kumpei Takahashi, Kenta Nagahori, Ning Qu, Miyuki Kuramasu, Yoshie Hirayanagi, Shogo Hayashi, Yuki Ogawa, Naoyuki Hatayama, Hayato Terayama, Kaori Suyama and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kumpei TakahashiDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Kenta NagahoriDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Ning QuDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan. quning@tokyo-med.ac.jp.ORCID http://orcid.org/0000-0001-5110-6719
Miyuki KuramasuDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Yoshie HirayanagiDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Shogo HayashiDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Yuki OgawaDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Naoyuki HatayamaDepartment of Anatomy, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Hayato TerayamaDepartment of Anatomy, Division of Basic Medical Science, Tokai University School of Medicine, Kanagawa, 259-1193, Japan.
Kaori SuyamaDepartment of Anatomy, Division of Basic Medical Science, Tokai University School of Medicine, Kanagawa, 259-1193, Japan.
Shuichi HiraiDepartment of Anatomy, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Kou SakabeDepartment of Anatomy, Division of Basic Medical Science, Tokai University School of Medicine, Kanagawa, 259-1193, Japan.
Masahiro ItohDepartment of Anatomy, Tokyo Medical University, Tokyo, 160-8402, Japan.
Tokyo Medical University · JPTokai University · JPAichi Medical University · JP

Funding

JSPS KAKENHI Grant C: 15K08937; 19K07876
6 · The paper itself

Abstract

backgroundInfertility and gonadal dysfunction are well known side-effects by cancer treatment in males. In particularly, chemotherapy and radiotherapy induced testicular damage, resulting in prolonged azoospermia. However, information regarding therapeutics to treat spermatogenesis disturbance after cancer treatment is scarce. Recently, we demonstrated that Goshajinkigan, a traditional Japanese medicine, can completely rescue severe busulfan-induced aspermatogenesis in mice. In this study, we aimed to detect the effects of Goshajinkigan on aspermatogenesis after irradiation.

methodsThis is animal research about the effects of traditional Japanese medicine on infertility after cancer treatment. C57BL/6 J male mice received total body irradiation (TBI: a single dose of 6Gy) at 4 weeks of age and after 60 days were reared a Goshajinkigan (TJ107)-containing or TJ107-free control diet from day 60 to day 120. Then, two untreated females were mated with a single male from each experimental group. On day 60, 120 and 150, respectively, the sets of testes and epididymis of the mice in each group after deep anesthetization were removed for histological and cytological examinations.

resultsHistological and histopathological data showed that 6Gy TBI treatment decreased the fertility rate (4/10) in the control diet group; in contrast, in the TJ107-diet group, the fertility rate was 10/10 (p < 0.05 vs. 6Gy group). Supplementation with TJ107 was found to rescue the disrupted inter-Sertoli tight junctions via the normalization of claudin11, occludin, and ZO-1 expression and reduce serum anti-germ cell autoantibodies.

conclusionsThese findings show the therapeutic effect on TBI-induced aspermatogenesis and the recovering disrupted gonadal functions by supplementation with TJ107.

Indexed as

SpermatogenesisAnimalsAzoospermiaDrugs, Chinese HerbalEpididymisFemaleJapanMaleMedicine, East Asian TraditionalMiceMice, Inbred C57BLRadiation Injuries, ExperimentalRadiation-Protective AgentsTestisDrugs, Chinese Herbalgosha-jinki-ganRadiation-Protective AgentsAnti-sperm antibody; Sertoli tight junctionsAspermatogenesisIrradiationTraditional Japanese medicine

Identifiers

PMID31829240
PMCPMC6907346
OpenAlexW2996606264

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.