ArticleBiology of sex differences2019
The angiotensin II type I receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats.
Article in Biology of sex differences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 24 citations in OpenAlex.
- AT1-AA induced hypertension during pregnancy contributes to developmental programming of hypertension in female offspring.Journal of reproductive immunology · 2025Article
- Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat.Pflugers Archiv : European journal of physiology · 2024Article
- Maternal Microvascular Dysfunction During and After Preeclamptic Pregnancy.Comprehensive Physiology · 2024Review
- The role of T cell stimulated agonistic autoantibodies to the angiotensin II type I receptor (AT1-AA) in mediating multiorgan dysfunction in IL-17 induced hypertension during pregnancy.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Regulation of vascular angiotensin II type 1 and type 2 receptor and angiotensin-(1-7)/MasR signaling in normal and hypertensive pregnancy.Biochemical pharmacology · 2024Review
- Blood-Brain Barrier Dysfunction in Hypertensive Disorders of Pregnancy.Current hypertension reports · 2023Review
- AT1-AA Infusion during Pregnancy Impairs CBF Autoregulation Postpartum.International journal of cerebrovascular disease and stroke · 2023Article
- Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia?Physiological reports · 2022Review
- Animal models of preeclampsia: investigating pathophysiology and therapeutic targets.American journal of obstetrics and gynecology · 2022Review
- Angiotensin II type 1 receptor agonistic autoantibody blockade improves postpartum hypertension and cardiac mitochondrial function in rat model of preeclampsia.Biology of sex differences · 2021Article
- Regulation of cerebral blood flow in humans: physiology and clinical implications of autoregulation.Physiological reviews · 2021Review
- Interleukin-17 induces hypertension but does not impair cerebrovascular function in pregnant rats.Pregnancy hypertension · 2021Article
- Maternal microvascular dysfunction during preeclamptic pregnancy.Clinical science (London, England : 1979) · 2021Review
- Neurology of Preeclampsia and Related Disorders: an Update in Neuro-obstetrics.Current pain and headache reports · 2021Review
- Preeclampsia: Linking Placental Ischemia with Maternal Endothelial and Vascular Dysfunction.Comprehensive Physiology · 2020Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPlacental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema. However, the factors that contribute to these cerebral abnormalities are not clear. Several lines of evidence suggest that angiotensin II can impact cerebrovascular function; however, the role of the renin angiotensin system in cerebrovascular function during placental ischemia has not been examined. We tested whether the angiotensin type 1 (AT1) receptor contributes to impaired CBF autoregulation in pregnant rats with placental ischemia caused by surgically reducing uterine perfusion pressure.
methodsPlacental ischemic or sham operated rats were treated with vehicle or losartan from gestational day (GD) 14 to 19 in the drinking water. On GD 19, we assessed CBF autoregulation in anesthetized rats using laser Doppler flowmetry.
resultsPlacental ischemic rats had impaired CBF autoregulation that was attenuated by treatment with losartan. In addition, we examined whether an agonistic autoantibody to the AT1 receptor (AT1-AA), reported to be present in preeclamptic women, contributes to impaired CBF autoregulation. Purified rat AT1-AA or vehicle was infused into pregnant rats from GD 12 to 19 via mini-osmotic pumps after which CBF autoregulation was assessed. AT1-AA infusion impaired CBF autoregulation but did not affect brain water content.
conclusionsThese results suggest that the impaired CBF autoregulation associated with placental ischemia is due, at least in part, to activation of the AT1 receptor and that the RAS may interact with other placental factors to promote cerebrovascular changes common to preeclampsia.
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