Evidence map›Paper›PMID 31829229›Full record

ArticleBiomedical engineering online2019

Effect of strontium-containing on the properties of Mg-doped wollastonite bioceramic scaffolds.

Su Wang, Linlin Liu, Xin Zhou, Danfeng Yang, Zhang'ao Shi, Yongqiang Hao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical engineering online, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Su WangSchool of Mechanical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Linlin LiuSchool of Mechanical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China. 1102584187@qq.com.ORCID http://orcid.org/0000-0002-4511-8665
Xin ZhouSchool of Mechanical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Danfeng YangSchool of Mechanical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Zhang'ao ShiSchool of Mechanical Engineering, Sichuan University, Chengdu, 610065, Sichuan, China.
Yongqiang HaoShanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Sichuan University · CNShanghai Jiao Tong University · CN

Funding

National Key R&D Program of China 2016YFC1100600
6 · The paper itself

Abstract

backgroundBone scaffold is one of the most effective methods to treat bone defect. The ideal scaffold of bone tissue should not only provide space for bone tissue growth, but also have sufficient mechanical strength to support the bone defect area. Moreover, the scaffold should provide a customized size or shape for the patient's bone defect.

methodsIn this study, strontium-containing Mg-doped wollastonite (Sr-CSM) bioceramic scaffolds with controllable pore size and pore structure were manufactured by direct ink writing 3D printing. Biological properties of Sr-CSM scaffolds were evaluated by apatite formation ability, in vitro proliferation ability of rabbit bone-marrow stem cells (rBMSCs), and alkaline phosphatase (ALP) activity using β-TCP and Mg-doped wollastonite (CSM) scaffolds as control. The compression strength of three scaffold specimens was probed after completely drying them while been submerged in Tris-HCl solution for 0, 2,4 and 6 weeks.

resultsThe mechanical test results showed that strontium-containing Mg-doped wollastonite (Sr-CSM) scaffolds had acceptable initial compression strength (56 MPa) and maintained good mechanical stability during degradation in vitro. Biological experiments showed that Sr-CSM scaffolds had a better apatite formation ability. Cell experiments showed that Sr-CSM scaffold had a higher cell proliferation ability compared with β-TCP and CSM scaffold. The higher ALP activity of Sr-CSM scaffold indicates that it can better stimulate osteoblastic differentiation and bone mineralization.

conclusionsTherefore, Sr-CSM scaffolds not only have acceptable compression strength, but also have higher osteogenesis bioactivity, which can be used in bone tissue engineering scaffolds.

Indexed as

AnimalsBiocompatible MaterialsCalcium CompoundsCell ProliferationCeramicsCompressive StrengthMagnesiumMaterials TestingOsteogenesisPrinting, Three-DimensionalRabbitsSilicatesStrontiumTissue ScaffoldsBiocompatible MaterialsCalcium Compoundscalcium silicateMagnesiumSilicatesStrontiumBioceramic scaffoldsCompression strengthDirect ink writing 3D printingStrontium

Identifiers

PMID31829229
PMCPMC6907205
OpenAlexW2995407895

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.