ArticleBMC health services research2019
Take -home naloxone rescue kits following heroin overdose in the emergency department to prevent opioid overdose related repeat emergency department visits, hospitalization and death- a pilot study.
Article in BMC health services research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Emergency care with lay responders in underserved populations: a systematic review.Bulletin of the World Health Organization · 2021Pooled it
- Evidence for state, community and systems-level prevention strategies to address the opioid crisis.Drug and alcohol dependence · 2019Pooled it
- Meeting people where they are, whenever they are here: the implementation of harm reduction programs in two U.S. emergency departments.International journal of emergency medicine · 2026Article
- Evaluation of an emergency department-based approach to reduce subsequent opioid overdoses.Journal of the American College of Emergency Physicians open · 2024Article
- Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff.BMC emergency medicine · 2024Article
- Electronic Advisories Increase Naloxone Prescribing Across Health Care Settings.Journal of general internal medicine · 2023Article
- Harm reduction strategies in acute care for people who use alcohol and/or drugs: A scoping review.PloS one · 2023Article
- 'It's the same thing as giving them CPR training': rural first responders' perspectives on naloxone.Harm reduction journal · 2022Article
- Implementing a Novel Statewide Network to Support Emergency Department-initiated Buprenorphine Treatment.The western journal of emergency medicine · 2022Review
- Prescribing Naloxone to High-Risk Patients in the Emergency Department: Is it Enough?Joint Commission journal on quality and patient safety · 2021Article
- A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- Drug overdose among women in intimate relationships: The role of partner violence, adversity and relationship dependencies.PloS one · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOpioid overdoses are at an epidemic in the United States causing the deaths of thousands each year. Project DAWN (Deaths Avoided with Naloxone) is an opioid overdose education and naloxone distribution program in Ohio that distributes naloxone rescue kits at clinics and in the emergency departments of a single hospital system.
methodsWe performed a retrospective analytic cohort study comparing heroin overdose survivors who presented to the emergency department and were subsequently discharged. We compared those who received a naloxone rescue kit at discharge with those who did not. Our composite outcome was repeat opioid overdose related emergency department visit(s), hospitalization and death at 0-3 months and at 3-6 months following emergency department overdose. Heroin overdose encounters were identified by ICD- 9 or 10 codes and data was abstracted from the electronic medical record for emergency department patients who presented for heroin overdose and were discharged over a 31- month period between 2013 and 2016. Patients were excluded for previous naloxone access, incarceration, suicidal ideation, admission to the hospital or death from acute overdose on initial emergency department presentation. Data was analyzed with the Chi- square statistical test.
resultsWe identified 291emergency department heroin overdose encounters by ICD-9 or 10 codes and were analyzed. A total of 71% of heroin overdose survivors received a naloxone rescue kit at emergency department discharge. Between the patients who did not receive a naloxone rescue kit at discharge, no overdose deaths occurred and 10.8% reached the composite outcome. Of the patients who received a naloxone rescue kit, 14.4% reached the composite endpoint and 7 opioid overdose deaths occurred in this cohort. No difference in mortality at 3 or 6 months was detected, p = 0.15 and 0.36 respectively. No difference in the composite outcome was detected at 3 or 6 months either, p = 0.9 and 0.99 respectively.
conclusionsOf our emergency department patients receiving a naloxone rescue kit we did not find a benefit in the reduction of repeat emergency department visits hospitalizations, or deaths following a non-fatal heroin overdose.
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