Evidence map›Paper›PMID 31828551›Full record

ReviewCurrent diabetes reports2019

Organoids from the Human Fetal and Adult Pancreas.

Jeetindra R A Balak, Juri Juksar, Françoise Carlotti, Antonio Lo Nigro, Eelco J P de Koning

Abstract readReview
In one paragraph

Review in Current diabetes reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Reprogramming the future: Capitalizing onIntractable & rare diseases research · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Engineered organoids for biomedical applications.Advanced drug delivery reviews · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Towards organoid culture without Matrigel.Communications biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jeetindra R A BalakDepartment of Internal Medicine, Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Juri JuksarHubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands.
Françoise CarlottiDepartment of Internal Medicine, Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Antonio Lo NigroHubrecht Institute for Developmental Biology and Stem Cell Research, Utrecht, The Netherlands.
Eelco J P de KoningDepartment of Internal Medicine, Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. e.dekoning@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewNovel 3D organoid culture techniques have enabled long-term expansion of pancreatic tissue. This review comprehensively summarizes and evaluates the applications of primary tissue-derived pancreatic organoids in regenerative studies, disease modelling, and personalized medicine. RECENT

findingsOrganoids derived from human fetal and adult pancreatic tissue have been used to study pancreas development and repair. Generated adult human pancreatic organoids harbor the capacity for clonal expansion and endocrine cell formation. In addition, organoids have been generated from human pancreatic ductal adenocarcinoma in order to study tumor behavior and assess drug responses. Pancreatic organoids constitute an important translational bridge between in vitro and in vivo models, enhancing our understanding of pancreatic cell biology. Current applications for pancreatic organoid technology include studies on tissue regeneration, disease modelling, and drug screening.

Indexed as

PancreasAdultAnimalsCell Culture TechniquesFetusHumansModels, BiologicalOrganoidsPrecision MedicineRegenerative Medicine3D cultureDevelopmentDiabetes Mellitus, Type 1OrganoidsPancreasRegenerationStem cells

Identifiers

PMID31828551
PMCPMC6906216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.