Evidence map›Paper›PMID 31828528›Full record

Trial reportEuropean journal of pediatrics2020

High flow nasal cannula and continuous positive airway pressure therapy in treatment of viral bronchiolitis: a randomized clinical trial.

Signe Vahlkvist, Louise Jürgensen, Amalie la Cour, Simone Markoew, Thomas Houmann Petersen, Poul-Erik Kofoed

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02618213 (Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis.), which is not on this map. Cited by 32 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 12 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02618213 nacompletednot on this map

Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis.

TypeinterventionalSponsorEsbjerg Hospital - University Hospital of Southern DenmarkRan2015 to 2018Enrolled50ConditionsRespiratory Syncytial Virus BronchiolitisArmsOptiflow Junior, Continous Positive Airway Pressure
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 12 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Respiratory support in paediatric patients with bronchiolitis: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
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  6. High-flow nasal cannula therapy for infants with bronchiolitis.The Cochrane database of systematic reviews · 2024
    Pooled it
  7. High flow nasal cannula for respiratory support in term infants.The Cochrane database of systematic reviews · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Signe VahlkvistDepartment of Pediatric and Adolecent Medicine, Hospital South West Jutland, Finsensgade 35, Esbjerg, 6700, Denmark. Signe.Vahlkvist@rsyd.dk.ORCID http://orcid.org/0000-0002-6981-4657
Louise JürgensenDepartment of Paediatrics and Adolescent Medicine, Hospital of Lillebaelt, Sygehusvej 24, Kolding, 6000, Denmark.
Amalie la CourDepartment of Pediatric and Adolecent Medicine, Hospital South West Jutland, Finsensgade 35, Esbjerg, 6700, Denmark.
Simone MarkoewDepartment of Pediatric and Adolecent Medicine, Hospital South West Jutland, Finsensgade 35, Esbjerg, 6700, Denmark.
Thomas Houmann PetersenDepartment of Paediatrics and Adolescent Medicine, Hospital of Lillebaelt, Sygehusvej 24, Kolding, 6000, Denmark.
Poul-Erik KofoedDepartment of Paediatrics and Adolescent Medicine, Hospital of Lillebaelt, Sygehusvej 24, Kolding, 6000, Denmark.
Lillebaelt Hospital · DKHospital South West Jutland · DKKolding Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous positive airway pressure (CPAP) has been used in infants with bronchiolitis for decades. Recently, high flow nasal cannula (HFNC) therapy was introduced. We conducted a trial of 50 children with bronchiolitis who were randomized to treatment with CPAP or HFNC. Objectives were to compare the development in respiratory rate, pCO2, and Modified Woods Clinical Asthma Score (M-WCAS) in young children with bronchiolitis, treated with CPAP or HFNC. Secondarily, to compare Neonatal Infant Pain Score (NIPS), treatment duration, treatment failure, and hospitalization length. Median age at inclusion was 2.8 (CPAP group) vs 2.1 months (HFNC group). Mean baseline pCO2 was 6.7 in both groups and mean respiratory rate was 60 vs 56 in the CPAP and HFNC group respectively. No differences were observed in development of respiratory rate, pCO2, or M-WCAS. NIPS was higher in the CPAP group. Treatment failure was scarce in both groups. No significant differences in treatment duration or length of hospitalization were observed.Conclusion: In infants and young children with bronchiolitis, HFNC may be an effective and pleasant alternative to CPAP. Larger multicenter studies are needed to further explore differences in treatment failure and treatment duration.Trial registration: www.clinicaltrial.gov. id NCT02618213, registration date December 1, 2015.What is Known:• CPAP has been used for many years for respiratory support in infant bronchiolitis. The method requires special staff skills and may be stressful to the child.• HFNC has been introduced as a newer tool.What is New:• In infants with bronchiolitis, HFNC and CPAP were comparable in decreasing respiratory rate, pCO2, and need for oxygen supply.• Pain score during therapy was lower in the HFNC group.

Indexed as

Bronchiolitis, ViralCannulaContinuous Positive Airway PressureFemaleHumansInfantInfant, NewbornMaleOxygen Inhalation TherapyPain MeasurementTreatment OutcomeBronchiolitisCPAPHFNCInfantsRespiratory syncytial virus

Identifiers

PMID31828528
OpenAlexW2995998636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.